The quantification of mortality resulting from the regular use of illicit opiates
The quantification of mortality resulting from the regular use of illicit opiates
复制标题
DOI：
10.1046/j.1360-0443.1999.9422216.x
复制
发表时间：
1999-02-01
期刊：
影响因子：
6
通讯作者：
Holman, CDJ
中科院分区：
文献类型：
--
作者：
Hulse, GK;English, DR;Holman, CDJ
目标/设计。与非法鸦片使用相关的死亡率估计为指导和监测地方、国家和国际政策和方案的人员提供了有用的信息。然而，大多数调查这种关联的研究规模都很小，对死亡率增加的估计不准确。目前的研究结合了多项国际研究的数据进行荟萃分析，以更准确地估计与非法阿片类药物使用相关的死亡率。由于不同国家和地区注射吸毒者的艾滋病毒感染情况差异很大，因此我们排除了艾滋病是导致死亡的主要原因的研究。仅纳入艾滋病相关死亡率占总死亡率低于 2% 的研究。发现。我们的研究结果显示，经常使用非法阿片类药物的人的死亡率比一般社区观察到的死亡率高出 13 倍多。据估计，15-39 岁澳大利亚人总死亡率的 9.4% 可归因于经常使用非法阿片类药物。将这一病因分数应用于 1992 年澳大利亚死亡率数据表明，大约有 401 名男性和 161 名女性因使用阿片类药物而死亡。这意味着男性和女性分别损失了大约 15429 人和 6261 人年（到 70 岁）。结论。非法鸦片使用者的死亡率比一般人群高约 13 莱姆。大量寿命损失反映了鸦片相关死亡发生在相对年轻的人群（15-39 岁）。相对风险估计也可应用于其他国家非法阿片类药物使用流行率的数据，以产生基于当地的病因分数和人年寿命损失估计。
Aims/Design. Estimates of mortality associated with illicit opiate use provide useful information to those directing and monitoring local, national and international policies and programmes. Most studies investigating the association have, however, been small with imprecise estimates of increased mortality. The current study combines data from a number of international studies in a meta-analysis to estimate more precisely mortality associated with illicit opiate use. Because HIV infection among injecting drug users differs dramatically between countries and localities, we excluded studies where AIDS was a major contributor to mortality. Studies were included only where AIDS-specific mortality accounted for less than 2% of total mortality. Findings. Our results show a mortality rate for people regularly using illicit opiates, which is more than 13 times greater than that observed for the general community. It is estimated that 9.4% of total mortality in Australians aged 15-39 years of age can be attributed to regular use of illicit opiates. Application of this aetiological fraction to Australian mortality data for 1992 indicate that approximately 401 male and 161 female deaths occurred as a result of opiate use. This represents some 15429 and 6261 person-years of life lost (to age 70) for males and females, respectively. Conclusions. The mortality rate for illicit opiate users is approximately 13 rimes greater than for the general population. The large number of years of life lost is reflective of the relatively young population (15-39 years of age) in which opiate-related mortality occurs. Relative risk estimates can also be applied to data on the prevalence of illicit opiate use in other countries to produce locally based aetiological fractions and estimates of person-years of life lost.