Anatomising proton NMR spectra with pure shift 2D J-spectroscopy: A cautionary tale
Anatomising proton NMR spectra with pure shift 2D J-spectroscopy: A cautionary tale
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DOI：
10.1016/j.cplett.2017.01.031
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发表时间：
2017-09-01
影响因子：
2.8
通讯作者：
Morris, Gareth A.
中科院分区：
文献类型：
--
作者：
Kiraly, Peter;Foroozandeh, Mohammadali;Morris, Gareth A.
60多年来，质子核磁共振光谱分析一直是结构测定的关键工具。2D j光谱是一种经典的工具，但常见的问题是难以获得准确结果所需的吸收模式线形，并且需要对最终的2D光谱进行45度剪切。本文报道了一种新的二维核磁共振方法，可以直接确定同核耦合，使用改进版的PSYCHE方法来抑制直接维度的耦合。该方法说明了将纯移位数据采集与多脉冲方法相结合时需要注意的问题。(C) 2017 Elsevier B.V.版权所有
Analysis of proton NMR spectra has been a key tool in structure determination for over 60 years. A classic tool is 2D J-spectroscopy, but common problems are the difficulty of obtaining the absorption mode lineshapes needed for accurate results, and the need for a 45 degrees shear of the final 2D spectrum. A novel 2D NMR method is reported here that allows straightforward determination of homonuclear couplings, using a modified version of the PSYCHE method to suppress couplings in the direct dimension. The method illustrates the need for care when combining pure shift data acquisition with multiple pulse methods. (C) 2017 Elsevier B.V. All rights reserved.