The modulation of microprojections on the lymphocyte membrane and the redistribution of membrane‐bound ligands, a correlation
The modulation of microprojections on the lymphocyte membrane and the redistribution of membrane‐bound ligands, a correlation
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淋巴细胞膜上微突出物的调节和膜结合配体的重新分布，相关性
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
L. Hägg
中科院分区：
文献类型：
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作者：
F. Loor;L. Hägg
免疫荧光显微镜可以检测淋巴细胞表面的微突起，并跟踪它们受各种环境条件的调节。 T 细胞和 B 细胞都相似地表达绒毛。除其他因素外，绒毛的表达在细胞冷冻后降低，在代谢抑制剂存在下增强，在影响微丝完整性的试剂存在下降低，对影响微管完整性的试剂相对不敏感，对pH敏感，被高剂量的凝集素抑制，并且依赖于配体缺乏可检测的膜抗原交联。
Immunofluorescence microscopy allows one to detect microprojections on the lymphocyte surface and to follow their modulation by various environmental conditions. Both T and B cells express villi similarly. Among other factors, the expression of villi is decreased after cell chilling, is enhanced in the presence of metabolic inhibitor, is decreased in the presence of an agent affecting microfilament integrity, is relatively insensitive to agents affecting microtubule integrity, is sensitive to the pH, is inhibited by high does of lectins and is dependent on the lack of detectable crosslinking of membrane antigens by the ligand.