Epidemiology of gallbladder cancer and trends in cholecystectomy rates in Scotland, 1968-1998
Epidemiology of gallbladder cancer and trends in cholecystectomy rates in Scotland, 1968-1998
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DOI：
10.1016/s0959-8049(03)00370-8
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发表时间：
2003-09-01
影响因子：
8.4
通讯作者：
Garden, OJ
中科院分区：
文献类型：
--
作者：
Wood, R;Fraser, LA;Garden, OJ
这项研究的目的是描述在过去的30年中，胆囊癌在苏格兰的流行病学。第二个目的是描述胆囊切除率的趋势，因为已经表明，胆囊切除术的良性胆囊疾病的发生率的变化可能会影响胆囊癌的流行病学。对1968-1998年苏格兰癌症登记和死亡率（胆囊癌）和出院（胆囊切除术）数据进行了回顾性分析。在苏格兰，女性胆囊癌的发病率和死亡率至少从1968年开始下降，男性从20世纪80年代末开始下降。虽然总体生存率仍然很低，但老年患者的生存率最近可能有所改善，富裕地区的患者生存率更高。胆囊炎发病率一直上升到1977年，然后下降，直到腹腔镜手术的引入使其恢复到以前观察到的水平。目前苏格兰胆囊癌发病率的下降可能部分与1977年之前胆囊切除术的发病率上升有关。需要进一步研究诊断和治疗阶段的变化，以调查老年胆囊癌患者近期生存率的明显改善。(C)2003 Elsevier Ltd.保留所有权利。
The aim of this study was to describe the epidemiology of gallbladder cancer in Scotland during the last 30 years. A secondary aim was to describe trends in cholecystectomy rates because it has been suggested that changing rates of cholecystectomy for benign gallbladder disease may be influencing the epidemiology of gallbladder cancer. A retrospective analysis of cancer registration and mortality (gallbladder cancer) and hospital discharge (cholecystectomy) data from Scotland in 1968-1998 was carried out. In Scotland the incidence of, and mortality from, gallbladder cancer have been falling in women since at least 1968, and in men since the late 1980s. Whilst overall survival remains poor, survival in older patients may have improved recently, and survival is better in patients from affluent areas. Cholecystectomy rates increased until 1977 then fell until the introduction of laparoscopic surgery caused them to return to the rates previously observed. The current declining incidence of gallbladder cancer in Scotland is probably, in part, related to the increasing cholecystectomy rates seen prior to 1977. Further studies addressing changes in stage at diagnosis and treatment provided are required to investigate the recent apparent improvement in survival of elderly gallbladder cancer patients. (C) 2003 Elsevier Ltd. All rights reserved.