Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions
Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions
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DOI：
10.1016/j.bbrc.2003.12.104
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发表时间：
2004-02-06
影响因子：
3.1
通讯作者：
Nagai, R
中科院分区：
文献类型：
--
作者：
Kawanami, D;Maemura, K;Nagai, R
抵抗素是一种脂肪细胞因子，在胰岛素抵抗的发展中起作用。在这项研究中，我们研究了血管内皮细胞的直接影响。抵抗素诱导VCAM-1和ICAM-1等粘附分子以及炎症标志物长五聚蛋白3的表达。匹伐他汀可部分抑制VCAM-1的表达。此外，脂联素（一种改善胰岛素抵抗的脂肪细胞因子）可抑制由β-内酰胺酶诱导的VCAM-1和ICAM-1。综上所述，这些结果表明，脂肪细胞因子如脂联素和脂联素浓度的平衡决定了血管系统的炎症状态，进而决定了动脉粥样硬化的进展。(C)2003年爱思唯尔公司All rights reserved.
Resistin is an adipocytokine which plays a role in the development of insulin resistance. In this study, we investigated the direct effect of resistin on vascular endothelial cells. Resistin induced the expression of adhesion molecules such as VCAM-1 and ICAM-1, and long pentraxin 3, a marker of inflammation. The induction of VCAM-1 by resistin was inhibited partially by pitavastatin. Moreover, the induction of VCAM-1 and ICAM-1 by resistin was inhibited by adiponectin, an adipocytokine that improves insulin resistance. Taken together, these results suggest that the balance in the concentrations of adipocytokines such as resistin and adiponectin determines the inflammation status of vasculature, and in turn the progress of atherosclerosis. (C) 2003 Elsevier Inc. All rights reserved.