Adverse drug events in children during hospitalization and after discharge in a Norwegian University Hospital
Adverse drug events in children during hospitalization and after discharge in a Norwegian University Hospital
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DOI：
10.1080/080352502753458021
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发表时间：
2002-01-01
期刊：
影响因子：
3.8
通讯作者：
Langslet, A
中科院分区：
文献类型：
--
作者：
Buajordet, I;Wesenberg, F;Langslet, A
挪威 Ullevaal 大学医院儿科住院儿童的药物不良事件 (ADE) 频率和特征是通过强化监测确定的。在 579 名接受药物治疗的儿童中，28% 经历了 ADE；入院时为 7%，住院期间为 18%，出院后为 9%。所有接受癌症治疗的儿童，其中 19% 接受抗感染药物治疗，15% 接受抗哮喘药物治疗，10% 接受影响神经系统药物治疗，均出现了 ADE。最常见的事件是胃肠道、中枢神经系统和皮肤反应，19% 的事件被认为是严重的。 ADE 导致 6% 的入院和 44% 需要干预。大多数不良事件是通过筛查患者记录发现的，其中医生大多描述需要干预的药物不良事件，而护士则描述不太严重的事件。家长报告了 14% 的事件。其中大部分是中枢神经系统反应。中枢神经系统反应可能比预期更常见，在调查儿童此类反应时，父母的观察很重要。结论：不良反应。 28%的患者出现主要是胃肠道、中枢神经系统和皮肤反应，与影响神经系统的药物、抗感染药和平喘药有关。家长对事件的报告是对患者记录筛选的有用补充。
The frequency and characteristics of adverse drug events (ADEs) in children hospitalized in the paediatric department of Ullevaal University Hospital, Norway, were determined using intensive monitoring. Of 579 children treated with drugs, 28% experienced ADEs; 7% at the time of admission, 18% during hospitalization and 9% after discharge. All children treated for cancer, 19% treated with anti-infective drugs, 15% treated with antiasthmatics and 10% treated with drugs affecting the nervous system experienced ADEs. The most frequent events were gastrointestinal, CNS- and skin reactions and 19% were considered as serious. ADEs caused 6% of the admissions and 44% required interventions. Most ADEs were found by screening patient records, where physicians mostly described adverse drug events requiring interventions and nurses described less serious events. Parents reported l4% of the events. of which a majority were CNS reactions. CNS reactions may be more common than expected and observations by parents are important when investigating such reactions in children.Conclusions: ADEs. mainly gastrointestinal, CNS and skin reactions related to drugs affecting the nervous system, anti-infectives and antiasthmatics, were seen in 28% of the patients. The reporting of events by parents was a useful supplement to the screening of patient records.