Correlation between expression of EGFR and the prognosis of patients with cervical carcinoma
Correlation between expression of EGFR and the prognosis of patients with cervical carcinoma
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DOI：
10.1006/gyno.2002.6803
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发表时间：
2002-10-01
影响因子：
4.7
通讯作者：
Kim, JW
中科院分区：
文献类型：
--
作者：
Kim, YT;Park, SW;Kim, JW
Objective.表皮生长因子受体（epidermal growth factor receptor，EGFR）基因在许多人类肿瘤中存在过表达，且EGFR过表达与肿瘤预后不良有关。然而，EGFR癌蛋白在宫颈癌预后中的作用仍存在争议。本研究旨在确定EGFR在宫颈癌患者中的预后价值。我们用酶联免疫吸附试验（ELISA）检测EGFR癌蛋白。结果与临床数据相关。结果。在所有探索的肿瘤中发现肿瘤中存在可测量水平的EGFR。水平变化范围很大，从31到2874 fmol/mg蛋白，中位数为582 fmol/mg蛋白，Q1、Q2和Q3四分位数分别为156、562和1047。EGFR过表达与无病期（P = 0.03）和总生存期（P = 0.04）的预后受损相关。多因素分析显示，肿瘤EGFR在无病期（P = 0.002）和总生存期（P = 0.005）方面提供了预后信息，与FIGO分期和病灶大小这两个已建立的预后指标无关。我们的研究结果是一致的概念，EGFR赋予预后信息，除了所提供的FIGO阶段和病变大小的临床病理参数。(C)2002 Elsevier Science（美国）。
Objective. Overexpression of epidermal growth factor receptor (EGFR) gene has been detected in a large number of human tumors, in most of which the association between overexpression of EGFR and poor prognosis of the disease has been reported. However, the prognostic role of EGFR oncoprotein in cervical carcinoma remains controversial. The current study aimed to determine the prognostic value of EGFR in patients with cervical cancer.Methods. We measured EGFR oncoprotein with an enzyme-linked immunosorbent assay (ELISA). Results were correlated to clinical data.Results. The presence of measurable levels of EGFR in the tumor was found in all of the explored tumors. The levels varied widely from 31 to 2874 fmol/mg protein with a median at 582 fmol/mg protein, and Q1, Q2, and Q3 quartiles were 156, 562, and 1047, respectively. Overexpression of EGFR was associated with an impaired prognosis with respect to disease-free interval (P = 0.03) and overall survival (P = 0.04). Multivariate analysis revealed that tumor EGFR provided prognostic information with respect to disease-free interval (P = 0.002) and overall survival (P = 0.005) independently of the two established prognosticators, FIGO stage and lesion size.Conclusion. Our results are consistent with the concept that EGFR confers prognostic information in addition to that provided by the established clinicopathologic parameters of FIGO stage and lesion size. (C) 2002 Elsevier Science (USA).