Long noncoding RNAs in psychiatric disorders.
Long noncoding RNAs in psychiatric disorders.
复制标题
DOI：
10.1097/ypg.0000000000000129
复制
发表时间：
2016-06
影响因子：
0.9
通讯作者：
Luo X
中科院分区：
文献类型：
--
作者：
Zuo L;Tan Y;Wang Z;Wang KS;Zhang X;Chen X;Li CS;Wang T;Luo X
长非编码 RNA (lncRNA) 是长度超过 200 个核苷酸的非蛋白质编码转录物。其中许多 lncRNA 具有调节功能，最近已成为控制基本生物过程的主要参与者。这里我们回顾一下lncRNA的定义、分布、鉴定、数据库、分析、分类和功能。我们还讨论了 lncRNA 在精神疾病病因过程中的潜在作用以及对临床诊断和治疗的影响。
Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Many of these lncRNAs have regulatory functions and have recently emerged as major players in governing fundamental biological processes. Here we review the definition, distribution, identification, databases, analysis, classification and functions of lncRNAs. We also discuss the potential roles of lncRNAs in the etiological processes of psychiatric disorders and the implications for clinical diagnosis and treatment.