In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus
In vitro synergistic effects of baicalin with oxytetracycline and tetracycline against Staphylococcus aureus
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DOI：
10.1093/jac/dkr108
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发表时间：
2011-06-01
影响因子：
5.2
通讯作者：
Kokoska, Ladislav
中科院分区：
文献类型：
--
作者：
Novy, Pavel;Urban, Jan;Kokoska, Ladislav
目的：本研究考察了黄芩苷（黄芩属植物黄芩的黄酮成分）与黄芩甙（黄芩甙）的体外协同作用，方法：采用微量肉汤稀释法测定土霉素和四环素对金黄色葡萄球菌的最低抑菌浓度（MIC），并以分数抑菌浓度指数（FICI）之和评价其联合作用
Objectives: In this study we examined the in vitro synergistic effect of baicalin, the flavone constituent of Scutellaria spp., in combinations with oxytetracycline and tetracycline on the growth of Staphylococcus aureus.Methods: The MICs were determined by the broth microdilution method and the effect of combinations was evaluated according to the sum of fractional inhibitory concentration indices (FICIs).Results: Synergistic activity (FICI