NASAL CYTOKINE PRODUCTION IN VIRAL ACUTE UPPER RESPIRATORY-INFECTION OF CHILDHOOD
NASAL CYTOKINE PRODUCTION IN VIRAL ACUTE UPPER RESPIRATORY-INFECTION OF CHILDHOOD
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DOI：
10.1093/infdis/171.3.584
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发表时间：
1995-03-01
影响因子：
6.4
通讯作者：
BECKER, S
中科院分区：
文献类型：
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作者：
NOAH, TL;HENDERSON, FW;BECKER, S
日托中心的儿童接受了一系列鼻腔灌洗，以评估急性上呼吸道感染（URI）期间鼻腔细胞因子的表达。与基线相比，急性URI期间鼻灌洗液中的白细胞介素（IL）-1 β、IL-8、IL-6和肿瘤坏死因子-α（TNF-α）显著升高，2-4周后，除TNF-α外，其他均显著降低。呼吸道合胞病毒阳性和阴性疾病的细胞因子模式没有显着差异。一个亚组的儿童还接受了下鼻甲下的浅表粘膜活检。在急性URI期间，9名受试者中有7名的活检细胞（90%-95%上皮细胞）显示IL-1 β、IL-8和IL-6的转录物增加，表明上皮细胞可能是急性URI期间细胞因子的一个来源。结果表明，学龄前儿童急性URI期间鼻分泌物中的炎性细胞因子升高。因此，细胞因子可能参与呼吸道病毒诱导的炎症的调节。
Children in a day care center underwent serial nasal lavages in order to assess nasal cytokine expression during acute upper respiratory infections (URI). Interleukin (IL)-1 beta, IL-8, IL-6, and tumor necrosis factor-alpha (TNF-alpha) were markedly elevated in nasal lavage fluid during acute URI compared to baseline, and all except TNF-alpha decreased significantly by 2-4 weeks later. Cytokine patterns in respiratory syncytial virus-positive and-negative illnesses did not differ significantly. A subgroup of children also underwent superficial mucosal biopsy under the inferior nasal turbinate. During acute URI, biopsy cells (90%-95% epithelial) showed increased transcripts for IL-1 beta, IL-8, and IL-6 in 7 of 9 subjects, suggesting that epithelial cells may be one source of cytokines during acute URI. The results show that inflammatory cytokines are elevated in nasal secretions during acute URI in preschool children. Thus, cytokines are likely to participate in regulation of respiratory virus-induced inflammation.