Magnetic Particle Imaging for High Temporal Resolution Assessment of Aneurysm Hemodynamics.
Magnetic Particle Imaging for High Temporal Resolution Assessment of Aneurysm Hemodynamics.
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DOI：
10.1371/journal.pone.0160097
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Buhk JH
中科院分区：
文献类型：
--
作者：
Sedlacik J;Frölich A;Spallek J;Forkert ND;Faizy TD;Werner F;Knopp T;Krause D;Fiehler J;Buhk JH
这项工作的目的是展示磁粒子成像 (MPI) 评估通过增材制造获得的真实 3D 动脉瘤模型中的血流动力学的能力。将 MPI 与磁共振成像 (MRI) 和动态数字减影血管造影 (DSA) 进行比较。动脉瘤模型具有囊状形态（7毫米圆顶高度，5毫米横截面，3-4毫米颈部，3.5毫米载瘤动脉直径），并连接到提供生理流量（250毫升/分钟）和脉动速率（70次/分钟）的蠕动泵。高分辨率（4 小时长）4D 相衬血流定量 (4D pc-fq) MRI 用于直接评估模型的血流动力学。通过近端放置的导管注射造影剂（3 秒内 3 mL 体积）进行动态 MPI、MRI 和 DSA。 4D pc-fq 测量显示明显的脉动流速 (20-80 cm/s) 以及较低的流速和动脉瘤内的涡流。所有三种动态方法（MPI、MRI 和 DSA）也显示出动脉瘤内清晰的脉动模式以及延迟的造影剂动态，这很可能是由动脉瘤内的涡流引起的。由于 MPI 和 DSA 的高时间分辨率，可以通过模型跟踪造影剂推注并估计平均流速（约 60 cm/s），这与 4D pc-fq 测量结果一致。无电离辐射、4D 高分辨率 MPI 方法是一种非常有前途的人体血流动力学成像和表征工具。它有可能克服其他模式的某些缺点，例如动态 MRI 的时间分辨率相当低和 DSA 的有限 2D 特性。此外，增材制造是将强大的临床前技术转化为临床的关键。
The purpose of this work was to demonstrate the capability of magnetic particle imaging (MPI) to assess the hemodynamics in a realistic 3D aneurysm model obtained by additive manufacturing. MPI was compared with magnetic resonance imaging (MRI) and dynamic digital subtraction angiography (DSA). The aneurysm model was of saccular morphology (7 mm dome height, 5 mm cross-section, 3–4 mm neck, 3.5 mm parent artery diameter) and connected to a peristaltic pump delivering a physiological flow (250 mL/min) and pulsation rate (70/min). High-resolution (4 h long) 4D phase contrast flow quantification (4D pc-fq) MRI was used to directly assess the hemodynamics of the model. Dynamic MPI, MRI, and DSA were performed with contrast agent injections (3 mL volume in 3 s) through a proximally placed catheter. 4D pc-fq measurements showed distinct pulsatile flow velocities (20–80 cm/s) as well as lower flow velocities and a vortex inside the aneurysm. All three dynamic methods (MPI, MRI, and DSA) also showed a clear pulsation pattern as well as delayed contrast agent dynamics within the aneurysm, which is most likely caused by the vortex within the aneurysm. Due to the high temporal resolution of MPI and DSA, it was possible to track the contrast agent bolus through the model and to estimate the average flow velocity (about 60 cm/s), which is in accordance with the 4D pc-fq measurements. The ionizing radiation free, 4D high resolution MPI method is a very promising tool for imaging and characterization of hemodynamics in human. It carries the possibility of overcoming certain disadvantages of other modalities like considerably lower temporal resolution of dynamic MRI and limited 2D characteristics of DSA. Furthermore, additive manufacturing is the key for translating powerful pre-clinical techniques into the clinic.