Diabetes and cognitive function in a middle-aged cohort - Findings from the Whitehall II study
Diabetes and cognitive function in a middle-aged cohort - Findings from the Whitehall II study
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DOI：
10.1212/01.wnl.0000184521.80820.e4
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发表时间：
2005-11-22
期刊：
影响因子：
9.9
通讯作者：
Marmot, M
中科院分区：
文献类型：
--
作者：
Kumari, M;Marmot, M
目的：比较中年队列中糖尿病、糖耐量受损和血糖正常者的认知能力。方法：作者分析了1985 - 1988年（基线）开始的前瞻性职业队列研究的数据。糖尿病根据1992 - 1993年（第3期）和1997 - 1999年（第5期）进行的口服葡萄糖耐量试验以及基线、1989年（第2期）、第3期、1995年（第4期）和第5期研究问卷中自我报告的糖尿病诊断进行分类。在第5阶段对4,020名男性和1,627名女性进行了一系列认知测试（记忆、Alice Heim 4 [AH 4]、Mill Hill词汇测试、音素流畅性和分类流畅性），平均年龄为56岁，无卒中症状。结果：在第5阶段，共有208名男性（5%）和101名女性（6%）患有糖尿病，而405名男性（10%）和192名女性（12%）患有糖耐量受损。与未患糖尿病的患者相比，患有糖尿病的患者在AH 4中表现不佳的风险增加（男性：OR，2.45; 95% CI，1.77至3.38;女性：OR，1.83; 95% CI，1.09至3.08）。这些影响与年龄、社会地位、血管问题和健康相关行为无关。葡萄糖耐量受损与任何认知指标无关。结论：2型糖尿病与中年男性和女性在某些认知方面的表现差有关。
Objective: To compare cognitive performance in those with diabetes, impaired glucose tolerance, and normoglycemia in a middle-aged cohort. Methods: The authors analyzed data from a prospective occupational cohort study begun in 1985 - 1988 (baseline). Diabetes was classified from oral glucose tolerance tests that were performed in 1992 - 1993 (phase 3) and 1997 - 1999 (phase 5) and self reported diagnosis of diabetes from questionnaire at baseline, 1989 (phase 2), phase 3, 1995 (phase 4), and phase 5 of the study. A battery of cognitive tests (memory, Alice Heim 4 [AH 4], Mill Hill vocabulary test, phonemic fluency, and categorical fluency) were measured at phase 5 in 4,020 men and 1,627 women with a mean age of 56 and free of symptoms of stroke. Results: At phase 5, a total of 208 (5%) men and 101 (6%) women had diabetes while 405 (10%) men and 192 (12%) women had impaired glucose tolerance. Those with diabetes were at increased risk of poor performance in AH 4 compared to those without (men: OR, 2.45; 95% CI, 1.77 to 3.38; women: OR, 1.83; 95% CI, 1.09 to 3.08). These effects were independent of age, social position, vascular problems, and health- related behaviors. Impaired glucose tolerance was not related to any measure of cognition. Conclusions: Type 2 diabetes is associated with poor performance in some aspects of cognition in middle- aged men and women.