Relationship between Alcohol Consumption and Serum Adiponectin Levels: The Takahata Study-A Cross-Sectional Study of a Healthy Japanese Population
Relationship between Alcohol Consumption and Serum Adiponectin Levels: The Takahata Study-A Cross-Sectional Study of a Healthy Japanese Population
复制标题
DOI：
10.1210/jc.2009-1862
复制
发表时间：
2010-08-01
影响因子：
5.8
通讯作者：
Kawata, Sumio
中科院分区：
文献类型：
--
作者：
Nishise, Yuko;Saito, Takafumi;Kawata, Sumio
内容：饮酒与血清脂联素水平之间的关系在亚洲人群中尚未得到充分探讨。目的：我们的目标是确定饮酒是否与健康日本人群脂联素水平的变化有关。设计：这是一项横断面研究。设置：受试者是从健康检查项目的参与者中招募的。参与者：本研究包括2932名受试者（1306名男性和1626名女性）。主要结果测量：每周或每日总酒精摄入量对血清脂联素水平的影响进行了评价。此外，临床性状与血清脂联素水平的相关性进行了研究。结果：男性饮酒与血清脂联素水平下降呈弱相关[斯皮尔曼有序相关系数（r（s））= -0.141; P < 0.001]，女性相关性更弱（r（s）= -0.055; P = 0.025）。多变量分析表明，酒精消费是独立与hypoadiponectinemia.Conclusion：相反，从美国和欧洲的报告之间的白色和黑色科目，我们的研究表明，亚洲受试者的酒精摄入量和血清脂联素水平之间呈负相关，这表明种族差异的影响，酒精消费对血清脂联素水平。（临床内分泌代谢杂志95：3828-3835，2010）
Context: The relationship between alcohol consumption and serum adiponectin levels has not been fully explored in an Asian population.Objective: Our goal was to determine whether alcohol consumption is associated with a change in adiponectin levels in a healthy Japanese population.Design: This was a cross-sectional study.Setting: Subjects were recruited from participants in a health check-up program.Participants: This study included 2932 subjects (1306 men and 1626 women).Main Outcome Measures: The effects of total weekly or daily volume of ethanol intake on serum adiponectin levels were evaluated. In addition, the correlation of clinical traits with serum adiponectin levels was examined. A multivariate regression model was used to control for possible confounding factors.Results: Alcohol consumption was weakly correlated with decreased serum adiponectin levels in men [Spearman's ordered correlation coefficient (r(s)) = -0.141; P < 0.001]; an even weaker correlation was seen in women (r(s) = -0.055; P = 0.025). Multivariate analysis demonstrated that alcohol consumption was independently associated with hypoadiponectinemia.Conclusion: In contrast to reports from the United States and Europe among White and Black subjects, our study demonstrated an inverse association between alcohol intake and serum adiponectin levels in Asian subjects, suggesting ethnic differences in the effects of alcohol consumption on serum adiponectin levels. (J Clin Endocrinol Metab 95: 3828-3835, 2010)