Subclinical hepatitis E virus (HEV) infection detected by nucleic acid amplification test on blood donation: short-term positivity for immunoglobulin G class of antibody against HEV
Subclinical hepatitis E virus (HEV) infection detected by nucleic acid amplification test on blood donation: short-term positivity for immunoglobulin G class of antibody against HEV
复制标题
献血核酸扩增检测发现亚临床戊型肝炎病毒（HEV）感染：HEV免疫球蛋白G类抗体短期阳性
DOI：
10.1007/s12328-022-01635-3
复制
发表时间：
2022
影响因子：
1
通讯作者：
Okamoto Hiroaki
中科院分区：
文献类型：
--
作者：
Hasegawa Izumi;Nakano Tatsunori;Koguchi Hiroki;Jinno Naruomi;Hirashima Noboru;Nagashima Shigeo;Takahashi Masaharu;Murata Kazumoto;Okamoto Hiroaki
通过献血核酸扩增检测发现一例戊型肝炎病毒（HEV）亚临床感染。患者随访至献血后第220天，但在整个观察期内未出现症状。天冬氨酸转氨酶和丙氨酸转氨酶水平在第37天达到最大值，略有增加，但从第67天至第220天保持在正常范围内。第13天初次检查时，戊型肝炎病毒RNA的含量为1.1 × 102拷贝/毫升，到第37天增加到2.8 × 103拷贝/毫升。从第67天到第220天未检测到。抗HEV免疫球蛋白G类抗体（抗HEV IgG）在第37天低于临界值，第67天超过临界值为阳性，伴随肝功能正常化和HEV RNA阴性转换。此后，滴度逐渐降低，在第163天降至临界值以下，并持续为阴性直至第220天。虽然抗-HEVIgG阳性的持续时间通常被认为是长的，但该亚临床病例仅在126天内。需要进一步研究以确定抗-HEVIgG短期阳性是否是亚临床HEV感染的典型表现。
A case of subclinical hepatitis E virus (HEV) infection was detected by nucleic acid amplification test on blood donation. The patient was followed-up until day 220 after the blood donation but showed no symptoms throughout the observation period. Aspartate aminotransferase and alanine aminotransferase levels reached the maximum values on day 37 with a slight increase but remained in normal ranges from day 67 to 220. The quantity of HEV RNA at the initial examination on day 13 was 1.1 × 102copies/mL, which increased to 2.8 × 103copies/mL by day 37. It was not detected from day 67 to 220. Immunoglobulin G class antibody to HEV (anti-HEV IgG) was below the cut-off value until day 37 and exceeded the cut-off value to positive on day 67, accompanied by normalization of liver function and negative conversion of HEV RNA. Thereafter, the titer decreased gradually, falling below the cut-off value on day 163, and continuing negative until day 220. Although the persistent duration of anti-HEV IgG positive is believed to be generally long, it was within only 126 days for this subclinical case. Further investigation is needed to determine whether short-term positivity for anti-HEV IgG is typical in subclinical HEV infection.