Flumazenil does not antagonize the cardiac effects of midazolam in the isolated rat heart-lung preparation
Flumazenil does not antagonize the cardiac effects of midazolam in the isolated rat heart-lung preparation
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氟马西尼在离体大鼠心肺制剂中不拮抗咪达唑仑的心脏作用
DOI：
10.1007/bf02471389
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发表时间：
1996
影响因子：
2.8
通讯作者：
T. Kumazawa
中科院分区：
文献类型：
--
作者：
Toshihiro Nakamura;S. Kashimoto;A. Nonaka;T. Kumazawa
研究咪达唑仑和氟马西尼对离体大鼠心肺制剂心功能和代谢的影响。Wistar大鼠随机分为5组（每组8只）：(1)对照组（生理盐水）；(2)氟马西尼（1.3×10−5M）；(3)氟马西尼（10−4M）；(4)咪达唑仑（60μg·ml−1）；(5)咪达唑仑（60μg·ml−1）和氟马西尼（1.3×10−5M）。与对照组相比，咪达唑仑组和咪达唑仑联用氟马西尼组的收缩压和计算左心室dP/dtmax均显著升高。咪达唑仑组心率明显低于对照组。氟马西尼组对血流动力学无明显影响。各组大鼠心肌组织ATP、乳酸、糖原浓度差异无统计学意义。在这项研究中，咪达唑仑降低了心率；然而，氟马西尼对心脏没有影响，也没有拮抗咪达唑仑的心脏作用。这些结果表明氟马西尼对心肌外周型苯二氮卓受体没有影响。
We examined the effects of midazolam and flumazenil on cardiac function and metabolism in the isolated rat heart-lung preparation. Wistar rats were divided into five groups (each group:n=8) as follows: (1) control (saline); (2) flumazenil (1.3×10−5M); (3) flumazenil (10−4M); (4) midazolam (60μg·ml−1); and (5) midazolam (60μg·ml−1) and flumazenil (1.3×10−5M). Systolic blood pressure and calculated left ventricular dP/dtmaximum in the midazolam or midazolam conbined with flumazenil groups increased significantly in comparison with those in the control group. Heart rate in the midazolam group was lower than that in the control group. However, in the flumazenil group, there were no effects on the hemodynamics. There were no significant differences in the myocardial tissue concentration of ATP, lactate, and glycogen in all groups. In this study, midazolam decreased heart rate; however, flumazenil had no effect on the heart, nor did it antagonize the cardiac effects of midazolam. These results suggest that flumazenil has no effect on the peripheraltype benzodiazepine receptor of the myocardium.