Indocyanine green angiography: Guided photodynamic therapy for polypoidal choroidal Vasculopathy
Indocyanine green angiography: Guided photodynamic therapy for polypoidal choroidal Vasculopathy
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DOI：
10.1016/j.ajo.2007.03.014
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发表时间：
2007-07-01
影响因子：
4.2
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Otani, Atsushi;Sasahara, Manabu;Yoshimura, Nagahisa
目的：报告采用吲吲吲胺绿血管造影（ICGA）引导光动力治疗（PDT）的中央凹下息肉样脉络膜血管病变（PCV）患者12个月的随访结果。设计：干预性、非比较性病例系列。方法：回顾性分析47只PCV眼的临床及血管造影资料，随访12个月。根据ICGA结果确定PDT的最大线性尺寸（GLD）。光学相干断层扫描（OCT）也用于评价治疗效果。结果：最小分辨视力角（VA; 0.58 +/- 0.37）的平均对数在3个月时显著提高至0.53 +/- 0.38 (P = 0.04)，在12个月时显著提高至0.46 +/- 0.40 （P = 0.02）。ICGA平均GLD （2682.3 +/- 1026.9 mm）明显小于假定的荧光素血管造影（FA） GLD (4043.6 +/- 1914.8 mm) （P = 0.0001）。在超过80%的病例中，观察到视网膜渗出性改变完全消退。82.2%的眼睛息肉样血管病变消失，但分支血管网络变化不大。最初的VA和GLD与VA的结果几乎没有相关性。结论：icga引导的PDT减少了激光照射的大小，是治疗PCV的有效方法。由于PCV可能在FA上表现为隐匿性脉络膜新生血管（CNV）， PCV应在治疗前使用ICGA诊断，因为PCV对适当治疗的反应可能与CNV不同。
PURPOSE: To report the 12-month follow,up results of subfoveal polypoidal choroidal vasculopathy (PCV) pa-, tients treated with indocyanine green angiography (ICGA)-guided photodynamic therapy (PDT).DESIGN: Interventional, noncomparative cases series.METHODS: A retrospective analysis of the clinical and angiographic data related to 47 PCV eyes that were followed up for 12 months was carried out. The greatest linear dimension (GLD) for PDT was determined based on the ICGA findings. Optical coherence tomography (OCT) also was used to evaluate the therapeutic effects.RESULTS: The mean logarithm of the minimum angle of resolution visual acuity (VA; 0.58 +/- 0.37) signifi, cantly improved to 0.53 +/- 0.38 at three months (P =.04) and to 0.46 +/- 0.40 at 12 months (P = .02). The average ICGA GLD (2682.3 +/- 1026.9 mm) was significantly (P = .0001) smaller than the presumed fluores, cein angiography (FA) GLD (4043.6 +/- 1914.8 mm). In more than 80% of cases, complete resolution of retinal exudative changes was observed. Although polypoidal vascular lesions disappeared in 82.2% of eyes, the branched vascular networks showed little change. The initial VA and GLD had little correlation with the VA outcome.CONCLUSIONS: ICGA-guided PDT reduces the size of laser exposure and is an effective treatment for PCV. Because PCV may appear as occult choroidal neovascularization (CNV) on FA, PCV should be diagnosed using ICGA before treatment because PCV may respond dif- ferently than CNV to appropriate treatment.