Eco‐Friendly Accomplishment of the Extended Kabachnik—Fields Reaction; a Solvent‐ and Catalyst‐Free Microwave‐Assisted Synthesis of α‐Aminophosphonates and α‐Aminophosphine Oxides.
Eco‐Friendly Accomplishment of the Extended Kabachnik—Fields Reaction; a Solvent‐ and Catalyst‐Free Microwave‐Assisted Synthesis of α‐Aminophosphonates and α‐Aminophosphine Oxides.
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扩展卡巴赫尼克场反应的环保实现；无溶剂和无催化剂的微波辅助合成α-氨基膦酸盐和α-氨基膦氧化物。
DOI：
10.1002/chin.200914179
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Anna Szekrényi
中科院分区：
文献类型：
--
作者：
G. Keglevich;Anna Szekrényi
卡巴尼克-菲尔兹反应可以在各种条件下进行。最近，“奇异”催化剂的应用变得流行起来，大多数情况下是在传统溶剂中，少数情况下是在离子液体中。使用一组简单的模型化合物，仍然扩大了所讨论的反应的范围，结果表明，最简单、最直接和最环保的方法是在不使用任何催化剂的情况下，将氧代组分、胺和>；P(O)H缩合成α-氨基膦或膦氧化物。在某些情况下，如果标题化合物是通过两步一锅法制备的，反应更明显。
The Kabachnik-Fields reaction may be carried out under a variety of conditions. More recently, the application of “exotic” catalysts, in most cases in traditional solvents and a few instances in ionic liquids, came into fashion. Using a pool of simple model compounds, still extending the scope of the reaction under discussion, it is shown that the simplest, most straightforward and most environmentally friendly accomplishment of the condensation of the oxo-component, the amine and the >P(O)H species to afford α-aminophosphonates or phosphine oxides involves microwave irradiation of the neat reaction mixture without the use of any catalyst. In some cases, the reaction is more clear-cut if the title compounds are prepared by a two-step one-pot procedure.