Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy
Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy
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DOI：
10.1034/j.1399-0039.2001.580302.x
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发表时间：
2001-09-01
期刊：
影响因子：
--
通讯作者：
Martín, J
中科院分区：
文献类型：
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作者：
Calzada, JE;Nieto, A;Martín, J
本研究探讨了CCR 5基因的两个多态性，即CCR 5 Δ 32缺失和CCR 5 59029 A ->G启动子点突变，在决定锥虫感染易感性以及发生冠心病中的可能作用。这些CCR 5多态性在85名血清阳性（无症状，n=53;心肌病，n=32）和87名血清阴性个体中进行了评估。我们人群中CCR 5 Delta 32等位基因的频率极低（0.009），无法分析其对克氏锥虫感染的可能影响。我们发现，总chagglutinase患者和对照组之间的CCR 5 59029启动子基因型或表型频率的分布没有差异。无症状心肌病患者中CCR 559029-A/G基因型显著高于无症状心肌病患者（P= 0.02; OR= 0.3395%CI0.10 ~ 0.94）。此外，与心肌病患者相比，无症状心肌病患者中CCR 5 590 2 9-G等位基因的存在也增加（P=0 0 2; OR=0.35，95% CI 0.12-0.96）。我们的数据表明，CCR 5 59029启动子多态性可能参与了对心肌病的不同易感性。
In this study we investigated the possible role of two CCR5 gene polymorphisms, CCR5 Delta 32 deletion and CCR5 59029 A -->G promoter point mutation, in determining the susceptibility to Trypanosoma cn,(Zi infection as well as in the development of chagasic heart disease. These CCR5 polymorphisms were assessed in 85 seropositive (asymptomatic, n=53; cardi- omyopathic, n=32) and 87 seronegative individuals. The extremely low frequency (0.009) of the CCR5 Delta 32 allele in our population did not allow us to analyse its possible influence on T cruzi infection. We found no differences in the distribution of CCR5 59029 promoter genotype or phenotype frequencies between total chagasic patients and controls. However, we observed that the CCR5 59029-A/G genotype was significantly increased in asymptomatic with respect to cardiomyopathic patients (P=0 02; OR=0 33 95% CI 0.10- 0.94). In addition, the presence of the CCR5 59029-G allele was also increased in asymptomatics when compared with cardiomyopathics (P=0 02;. OR=0.35, 95% CI 0.12-0.96). Our data suggest that the CCR5 59029 promoter polymorphism may be involved in a differential susceptibility to chagasic cardiomyopathy.