Onodera's prognostic nutritional index correlates with tumor immune environment and survival in patients with oral squamous cell carcinoma undergoing chemoradiotherapy
Onodera's prognostic nutritional index correlates with tumor immune environment and survival in patients with oral squamous cell carcinoma undergoing chemoradiotherapy
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DOI：
10.1016/j.tranon.2020.100850
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发表时间：
2020-12-01
影响因子：
5
通讯作者：
Nakayama, Hideki
中科院分区：
文献类型：
--
作者：
Yoshida, Ryoji;Gohara, Shunsuke;Nakayama, Hideki
治疗前的营养和免疫状态对预测各种类型的恶性肿瘤的生存结果是有用的。我们的目的是确定治疗前Onodera的预后营养指数（OPNI）对晚期口腔鳞状细胞癌（OSCC）患者接受确定性放化疗的结果的影响。我们回顾了2004年1月至2011年12月期间在我们机构接受确定性放化疗（CRT）治疗的47例OSCC患者。我们根据以下公式确定OPNI：10 x血清白蛋白（g/dL）+0.005 x总淋巴细胞计数（每μ L）。我们确定了最佳OPNI截止通过接收机工作特性分析。我们分析了OPNI状态与各种临床病理特征之间的关系，并评估了OPNI对预后的影响。我们检查了OPNI和全身炎症反应参数之间的关系，并分析了肿瘤内CD 8 + T细胞及其与OPNI的相关性。最佳OPNI截断值为42.7。Kaplan-Meier曲线分析显示，低OPNI与总生存率和病因特异性生存率显著相关。多变量分析显示，OPNI低与5年总生存率和病因特异性生存率低独立相关。OPNI与全身炎症反应参数显著相关。低OPNI组原发性肿瘤中的瘤内CD 8 + T细胞计数显著低于高OPNI组。目前的数据表明，治疗前的OPNI是一个有价值的独立预后指标的整体和原因特异性生存晚期口腔鳞癌后确定CRT。OPNI可反映口腔鳞癌的肿瘤免疫微环境特征。
Pretreatment nutritional and immunological status is useful for predicting survival outcomes for various types of malignant tumors. Our objective was to determine the impact of the pretreatment Onodera's prognostic nutritional index (OPNI) on outcomes of patients who underwent definitive chemoradiotherapy for advanced oral squamous cell carcinoma (OSCC). We reviewed 47 patients treated for OSCC with definitive chemoradiotherapy (CRT) at our institution between January 2004 and December 2011. We determined the OPNI according to the following formula: 10 x serum albumin (g/dL) + 0.005 x total lymphocyte count (per mu L). We determined the optimum OPNI cut-off through a receiver operating characteristic analysis. We analyzed the associations between OPNI status and various clinicopathological features and evaluated the effects of OPNI on the prognosis. We examined the relationships between OPNI and systemic inflammatory response parameters and analyzed intratumoral CD8+ T cells and their correlation with OPNI. The optimum OPNI cut-off was 42.7. A Kaplan-Meier curve analysis revealed that low OPNI was significantly associated with poor overall survival and cause-specific survival. The multivariate analysis revealed that low OPNI was independently correlated with poor 5 year overall survival and cause-specific survival. OPNI was significantly correlated with systemic inflammatory response parameters. Intratumoral CD8+ T cell counts in primary tumors were significantly lower for low OPNI than for high OPNI. The present data demonstrate that pretreatment OPNI is a valuable independent prognostic indicator of overall and cause-specific survival in advanced OSCC following definitive CRT. OPNI might reflect the tumor immune microenvironment characterization in OSCC.