Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
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DOI：
10.1073/pnas.040570597
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发表时间：
2000-03-14
影响因子：
11.1
通讯作者：
Chance, B
中科院分区：
文献类型：
--
作者：
Ntziachristos, V;Yodh, AG;Chance, B
我们展示了人体乳房体内的定量光学图像。在给予吲哚菁绿（ICG）增强对比度后，使用近红外漫射光学断层扫描（DOT）获得图像。对计划进行切除活检或手术的患者进行光学检查和磁共振成像（MRI）检查，以便获得可疑病变的准确图像配准和组织病理学信息。 ICG 增强光学图像与钆增强磁共振图像精确配准，验证了 DOT 对乳腺组织成像的能力。与简单的透照相反，我们发现 DOT 提供了外源组织发色团浓度的定位和定量。此外，我们使用 ICC（一种血浆中白蛋白结合的吸收染料）证明了根据可疑病变的量化增强来区分疾病的潜力。
We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG) for contrast enhancement. The optical examination was performed concurrently with a magnetic resonance imaging (MRI) exam on patients scheduled for excisional biopsy or surgery so that accurate image coregistration and histopathological information of the suspicious lesions was available. The ICG-enhanced optical images coregistered accurately with Gadolinium-enhanced magnetic resonance images validating the ability of DOT to image breast tissue. In contrast to simple transillumination, we found that DOT provides for localization and quantification of exogenous tissue chromophore concentrations. Additionally our use of ICC, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions.