Exosomes in the tumor microenvironment of cholangiocarcinoma: current status and future perspectives.
Exosomes in the tumor microenvironment of cholangiocarcinoma: current status and future perspectives.
复制标题
胆管癌肿瘤微环境中的外泌体：现状与未来展望
DOI：
10.1186/s12967-022-03294-x
复制
发表时间：
2022-03-07
影响因子：
7.4
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Zhao K;Li X;Shi Y;Lu Y;Qiu P;Deng Z;Yao W;Wang J
胆管癌（Cholangiocarcinoma，CCA）是一种侵袭性强、病死率高、预后差的恶性肿瘤。在全球范围内，过去几十年来，CCA的发病率不断增加，已发展成为严重危害人类健康的疾病。外泌体属于一类直径在40至150 nm范围内的细胞外囊泡（EV），可由所有活细胞释放。作为细胞间网络的通讯信使，外泌体携带各种各样的货物，如蛋白质、核酸、脂质和代谢物质，它们能够在不同的细胞类型之间传递生物信息以介导各种生理活动或病理变化。越来越多的研究表明，肿瘤微环境中的外泌体通过多种途径参与调节肿瘤的发生和发展。本文就exosomes在肿瘤中的研究进展作一综述，重点介绍exosomes在调节CCA发生发展中的作用。此外，外泌体作为CCA诊断和治疗靶点的潜在价值也进行了综述。
Cholangiocarcinoma (CCA) refers to an aggressive malignancy with a high fatality rate and poor prognosis. Globally, the morbidity of CCA is increasing for the past few decades, which has progressed into a disease that gravely endangers human health. Exosomes belong to a class of extracellular vesicles (EVs) with diameters ranging from 40 to 150 nm that can be discharged by all living cells. As communication messengers of the intercellular network, exosomes carry a diverse range of cargoes such as proteins, nucleic acids, lipids, and metabolic substances, which are capable of conveying biological information across different cell types to mediate various physiological activities or pathological changes. Increasing studies have demonstrated that exosomes in the tumor microenvironment participate in regulating tumorigenesis and progression via multiple approaches in the tumor microenvironment. Here, we reviewed the current research progress of exosomes in the context of cancer and particularly highlighted their functions in modulating the development of CCA. Furthermore, the potential values of exosomes as diagnostic and therapeutic targets in CCA were overviewed as well.