VERAPAMIL VS QUININE IN RECUMBENT NOCTURNAL LEG CRAMPS IN THE ELDERLY
VERAPAMIL VS QUININE IN RECUMBENT NOCTURNAL LEG CRAMPS IN THE ELDERLY
复制标题
DOI：
10.1001/archinte.148.9.1969
复制
发表时间：
1988-09-01
影响因子：
--
通讯作者：
WEIDLER, DJ
中科院分区：
文献类型：
--
作者：
BALTODANO, N;GALLO, BV;WEIDLER, DJ
在一项开放标签试验中，8名老年患者（年龄62至87岁）患有硫酸奎宁治疗难治性夜间腿部痉挛，我们排除了其他活动性疾病过程，并替代盐酸维拉帕米治疗（睡前120 mg）。在整个试验期间（持续8周），由初级保健医生每两周观察一次，由研究注册护士每夜观察一次，评估治疗反应。观察结果和报告的临床状况表明，当治疗从奎宁改为维拉帕米时，痉挛改善和消失。卧位夜间腿抽筋患者的这一显著改善是一个重要的发现，值得进一步研究。
In an open-labeled trial with eight elderly patients (aged 62 to 87 years) suffering from nocturnal leg cramps refractory to treatment with quinine sulfate, we ruled out other active disease processes and substituted verapamil hydrochloride therapy (120 mg at bedtime). Response to treatment was assessed by biweekly observations by the primary care physician and nightly by the research registered nurse for the entire duration of the trial, lasting eight weeks. Observations made and clinical conditions reported were indicative of improvement and disappearance of cramping when therapy was changed from quinine to verapamil. This noteworthy improvement in patients with recumbent nocturnal leg cramps is an important finding and merits further investigation.