Cytoplasmic dynein nomenclature.
Cytoplasmic dynein nomenclature.
复制标题
细胞质动力蛋白术语。
DOI：
10.1083/jcb.200508078
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发表时间：
2005-11-07
影响因子：
7.8
通讯作者：
Vallee, Richard B
中科院分区：
文献类型：
--
作者：
Pfister, K Kevin;Fisher, Elizabeth M C;Gibbons, Ian R;Hays, Thomas S;Holzbaur, Erika L F;McIntosh, J Richard;Porter, Mary E;Schroer, Trina A;Vaughan, Kevin T;Witman, George B;King, Stephen M;Vallee, Richard B
在文献中，细胞质动力蛋白复合物的亚基有各种各样的名称。因此，迫切需要一个更明确的命名共识声明。这对于哺乳动物细胞质动力蛋白尤其重要，其中许多亚基由多个基因编码。我们建议哺乳动物细胞质动力蛋白亚基基因和蛋白质的名称，反映了基因的系统发育关系和发表的研究澄清多肽的功能。这种命名法识别两种不同的细胞质动力蛋白复合物，并具有适应新亚基和亚型发现的灵活性。
A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes. We propose names for the mammalian cytoplasmic dynein subunit genes and proteins that reflect the phylogenetic relationships of the genes and the published studies clarifying the functions of the polypeptides. This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms.