Treatment of Streptococcus mutans biofilms with a nonthermal atmospheric plasma
Treatment of Streptococcus mutans biofilms with a nonthermal atmospheric plasma
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DOI：
10.1111/j.1472-765x.2007.02194.x
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发表时间：
2007-09-01
影响因子：
2.4
通讯作者：
Stoffels, E.
中科院分区：
文献类型：
--
作者：
Sladek, R. E. J.;Filoche, S. K.;Stoffels, E.
目的：一个非热大气等离子体，设计用于生物医学应用，测试其抗微生物活性对生物膜培养的一个关键的致龋细菌变形链球菌。在有和没有0.15%蔗糖的情况下生长变形杆菌生物膜。使用氯己定二葡萄糖酸盐冲洗液（0.2%）作为阳性抗菌参比品。蔗糖的存在下，在生长过程中的等离子体应用的频率被证明有显着的效果对治疗和抗菌activity.Conclusion的反应：一个单一的等离子体治疗1分钟的生物膜培养没有蔗糖造成的观察期内没有再生长。然而，无论是单一或重复的等离子体治疗1分钟，与0.15%的蔗糖培养的生物膜，生长只减少了。意义和影响的研究：总之，有可能是一个作用，非热等离子体疗法在牙科手术。蔗糖和相关的生长条件可能是治疗后口腔生物膜存活的一个因素。
Aims: A nonthermal atmospheric plasma, designed for biomedical applications, was tested for its antimicrobial activity against biofilm cultures of a key cariogenic bacterium Streptococcus mutans.Methods and Results: The Strep. mutans biofilms were grown with and without 0.15% sucrose. A chlorhexidine digluconate rinse (0.2%) was used as a positive antimicrobial reference. The presence of sucrose and the frequency of plasma application during growth were shown to have a significant effect on the response to treatment and antibacterial activity.Conclusion: A single plasma treatment for 1 min on biofilms cultured without sucrose caused no re-growth within the observation period. However, with either single or repeated plasma treatments of 1 min, on biofilms cultured with 0.15% sucrose, growth was only reduced.Significance and Impact of the Study: In summary, there may be a role for nonthermal plasma therapies in dental procedures. Sucrose and associated growth conditions may be a factor in the survival of oral biofilms after treatment.