Endocannabinoids facilitate the induction of LTP in the hippocampus
Endocannabinoids facilitate the induction of LTP in the hippocampus
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DOI：
10.1038/nn879
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发表时间：
2002-08-01
影响因子：
25
通讯作者：
Alger, BE
中科院分区：
文献类型：
--
作者：
Carlson, G;Wang, Y;Alger, BE
外源性大麻素破坏行为学习并阻碍海马中长时程增强（LTP）的诱导，而内源性大麻素（endocannabinoids）通过激活GABA能中间神经元上的大麻素CB1受体而瞬时抑制抑制性突触后电流（IPSC）。我们发现，释放内源性大麻素的大鼠CA1锥体细胞在此去极化诱导抑制抑制（DSI），使一个正常无效的列车兴奋性突触后电流（EPSC）诱导LTP在该细胞，但不是在邻近的细胞。通过显示内源性大麻素促进LTP诱导并帮助将LTP靶向单细胞，这些数据揭示了内源性大麻素的生理作用，并可能导致更好地了解其对行为和潜在临床用途的影响。
Exogenous cannabinoids disrupt behavioral learning and impede induction of long-term potentiation (LTP) in the hippocampus, yet endogenous cannabinoids (endocannabinoids) transiently suppress inhibitory post-synaptic currents (IPSCs),by activating cannabinoid CB1 receptors on GABAergic interneurons. We found that release of endocannabinoids by a rat CA1 pyramidal cell during this depolarization-induced suppression of inhibition (DSI),enabled a normally ineffective train of excitatory post-synaptic currents (EPSCs) to induce LTP in that cell, but not in neighboring cells. By showing that endocannabinoids facilitate LTP induction and help target LTP to single cells, these data shed new light on the physiological roles of endocannabinoids and may lead to a greater understanding of their effects on behavior and potential clinical use.