Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats
Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats
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DOI：
10.1021/jf0112421
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发表时间：
2002-03-13
影响因子：
6.1
通讯作者：
Terao, J
中科院分区：
文献类型：
--
作者：
Azuma, K;Ippoushi, K;Terao, J
考察了脂质、乳化剂和乙醇对槲皮素在大鼠体内吸收的影响，以提高槲皮素在大鼠体内的吸收效率。向大鼠给予150 μ mol/kg槲皮素水溶液（补充脂质和/或乳化剂或乙醇），并在给药后6 h从尾部采集血液。脂质（如卵磷脂和大豆油）或乳化剂（包括蔗糖脂肪酸酯、聚甘油脂肪酸酯和牛磺胆酸钠）的联合给药对槲皮素吸收无统计学显著影响，但这些成分反而增加了大鼠血浆中槲皮素和异鼠李素的结合形式的蓄积。而脂质和乳化剂的组合显著增强了槲皮素的吸收。溶剂中30%和50%（v/v）的乙醇以浓度依赖性方式提高槲皮素吸收效率。这些成分的槲皮素吸收增强作用似乎受到槲皮素在用于给药的相应载体中的溶解度的影响。乙醇对槲皮素的有效吸收没有帮助，因为需要高浓度。总之，脂质和乳化剂的组合对于增强槲皮素吸收是必要的。
The effects of lipids, emulsifiers, and ethanol on the absorption of orally administered quercetin in rats were investigated for its efficient intestinal absorption. Rats were administered 150 mumol/kg quercetin in water supplemented with lipids and/or emulsifiers, or ethanol, and blood was collected from the tail for 6 h after administration. Co-administration of lipids such as lecithin and soybean oil or emulsifiers including sucrose fatty acid ester, polyglycerol fatty acid ester, and sodium taurocholate had no statistically significant effects on quercetin absorption, although these constituents rather increased the accumulation of conjugated forms of quercetin and those of isorhamnetin in rat plasma. However, the combination of lipids and emulsifiers enhanced the absorption of quercetin significantly. Thirty and fifty percent (v/v) of the ethanol in the vehicle raised the efficiency of quercetin absorption in a concentration-dependent manner. Quercetin absorption-enhancing effects of these constituents seemed to be affected by quercetin's solubility in respective vehicles used for the administration. Ethanol is not helpful for the effective absorption of quercetin, as a high concentration is required. In conclusion, a combination of lipids and emulsifiers is necessary for enhancing quercetin absorption.