Simultaneous cisplatin fluorouracil infusion and radiation followed by surgical resection in regionally localized stage III, non-small cell lung cancer.
Simultaneous cisplatin fluorouracil infusion and radiation followed by surgical resection in regionally localized stage III, non-small cell lung cancer.
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针对局部 III 期非小细胞肺癌，同时进行顺铂氟尿嘧啶输注和放疗，然后进行手术切除。
DOI：
10.1016/s0003-4975(10)60173-7
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
C. Kittle
中科院分区：
文献类型：
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作者：
S. Taylor;Marion Trybula;P. Bonomi;L. Faber;M. Lee;S. Reddy;Susan C. Maffey;D. Mathisen;R. Jensik;C. Kittle
对64例Ⅲ期(M0)非小细胞肺癌患者采用顺铂氟尿嘧啶化疗加同步放射治疗，每隔一周5天一次。共4个周期(40Gy线)，随后尝试手术切除。对术前治疗的临床反应包括5例(8%)完全缓解，32例(48%)部分缓解。39例(61%)接受了计划手术，其中9例(23%)切除的标本组织学为阴性。临床评估未能预测组织学反应。中位随访17个月(2.4-29个月)，估计1年生存率为61%，中位生存期为16个月。
Sixty-four patients with stage III (M0) non–small cell lung cancel were treated with cisplatin fluorouracil infusion chemotherapy and simultaneous radiation therapy for 5 days every other week. A total of 4 cycles (40 Gy) was followed by attempted surgical resection. Clinical response to the preoperative treatment included 5 (8%) complete and 32 (48%) partial responses. Thirty-nine (61%) underwent the planned operation, and in 9 (23%) of these patients the resected specimens were histologically negative. Clinical assessment failed to predict histological response. With 17 months median follow-up (range, 2.4–29 months), estimated 1-year survival was 61% and median survival was 16 months for all patients.