DIABETES MELLITUS IN FRIEDREICHS ATAXIA
DIABETES MELLITUS IN FRIEDREICHS ATAXIA
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DOI：
10.1136/jnnp.31.3.226
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发表时间：
1968-01-01
影响因子：
11
通讯作者：
ROBINSON, N
中科院分区：
文献类型：
--
作者：
HEWER, RL;ROBINSON, N
糖尿病与弗里德赖希共济失调的关系不时有报道。如果这种关联被牢固地建立起来，它可能对这两种疾病的遗传背景和可能的病因学产生重要影响。Rossi（1893）似乎是第一个描述糖尿病并发Friedreich共济失调的人。1940年，Schlezinger和Goldstein在文献调查中发现了18个报告病例，并增加了两个他们自己的病例。阿什比和特威迪（Ashby and Tweedy，1953）又发现了11个病例，并报告了另外一对兄弟姐妹。Thoren（1962）共讨论了45个病例（5个来自文献，7个来自他自己）。Podolosky，Pothier，and Krall（1964）报道了另外两例，Niemann，Pemot，Manciaux，Tridon，Guinoiseau，and Charles（1964）报道了一个8岁儿童的糖尿病前期葡萄糖耐量曲线。瑞典Thoren（1962）对50例48岁以下的Friedreich共济失调患者进行了系统调查，发现9例已知糖尿病（发病率18%）。他对18名非糖尿病患者进行了静脉葡萄糖耐量试验，发现了一个轻微的异常。本文报告了113例Fried-reich共济失调患者中糖尿病的发生率。这些观察结果是弗里德赖希共济失调疾病分类学更广泛研究的一部分。
The association of diabetes mellitus with Friedreich's ataxia has been reported from time to time. If such an association were firmly established, it could have important implications for the genetic background and possible aetiology of the two diseases. Rossi (1893) appears to have been the first to describe theconcurrence of diabetes mellitus with Friedreich's ataxia. In 1940, Schlezinger and Goldstein ina survey of the literature found 18 reported cases and added two of their own. Ashby and Tweedy (1953) discovered 11 more cases and re-ported a further pair of siblings. Thoren (1962) was able to discuss a total of 45 cases (five additional ones from the literature andseven of his own). Podolosky, Pothier, and Krall (1964) have recorded two further cases, while Niemann, Pemot, Manciaux, Tridon, Guinoiseau, and Charles (1964) have reported a pre-diabetic glucose tolerance curve in a child aged 8.Most previous papers have simply reported single cases. However, Thoren (1962), in Sweden, made a systematic surveyof 50 patients with Friedreich's ataxia, all of whom were aged 48 years or less. He found nine cases of known diabetes mellitus (an incidence of 18%). He performed an intravenous glucose tolerance test on 18 of his non-diabetic patients and found one minor abnormality. In the present paper we report the frequency of diabetes mellitus in a series of 113 cases of Fried-reich's ataxia. Theseobservations are part ofa wider study of the nosology of Friedreich's ataxia.