BEHAVIORAL, NEUROENDOCRINE, AND BIOCHEMICAL EFFECTS OF 5-HYDROXYTRYPTOPHAN ADMINISTRATION IN PANIC DISORDER
BEHAVIORAL, NEUROENDOCRINE, AND BIOCHEMICAL EFFECTS OF 5-HYDROXYTRYPTOPHAN ADMINISTRATION IN PANIC DISORDER
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DOI：
10.1016/0165-1781(90)90096-n
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发表时间：
1990-03-01
影响因子：
11.3
通讯作者：
WESTENBERG, HGM
中科院分区：
文献类型：
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作者：
DENBOER, JA;WESTENBERG, HGM
应用L-5-羟色氨酸(5HTP)对20例惊恐障碍患者和20例健康对照进行治疗。受试者在300毫升生理盐水中加入60毫克5HTP。在给药前、给药期间和给药后2小时内，评估焦虑和抑郁症状。测定各时间点血浆5-羟色胺、3-甲氧基-4-羟乙二醇、皮质醇、β-内啡肽和褪黑素水平，并测定血小板内5-羟色胺(5-羟色胺)的动态变化。在注射5HTP期间和之后，尽管存在严重的副作用，但没有一名患者表现出焦虑或抑郁症状的增加。一些患者甚至体验了5htp的输液作为一种解脱。与患者相反，9名对照组受试者报告了抑郁的情绪，尽管没有注意到焦虑的增加。在患者和对照组中，5HTP输注导致血浆皮质醇和β-内啡肽水平显著增加，而血浆MHPG水平没有变化。5HTP给药后血浆褪黑激素显著升高，提示增加人体内5-羟色胺的利用率可能会影响褪黑素的合成。这项研究的结果与5HT2受体在恐慌症中存在超敏反应的假设不符。
L-5-Hydroxytryptophan (5HTP) was administered to 20 patients suffering from panic disorder and to 20 healthy controls. Subjects received 60 mg 5HTP in 300 ml saline solution. Before, during, and up to 2 hours after 5HTP administration, symptoms of anxiety and depression were assessed. In addition, plasma 5HTP, 3-methoxy-4-hydroxyethyglycol (MHPG), cortisol,β-endorphin, and melatonin levels were measured at several time points, and the kinetics of 5-hydroxytryptamine (5HT) in blood platelets were measured. During and after the infusion of 5HTP, none of the patients showed an increase in anxiety or depressive symptoms, despite the presence of severe side effects. Some patients even experienced the 5HTP infusion as a relief. In contrast to the patients, nine control subjects reported depressed mood, although no increases in anxiety were noted. In both patients and controls, the 5HTP infusion led to substantial increases in plasma cortisol andβ-endorphin levels, while the plasma MHPG level was unchanged. Plasma melatonin increased significantly after 5HTP administration, suggesting that increasing 5HT availability in man might affect melatonin synthesis. The results of this study are at odds with the hypothesis that there is a supersensitivity of 5HT2receptors in panic disorder.