Impaired facial emotion recognition in early-onset right mesial temporal lobe epilepsy
Impaired facial emotion recognition in early-onset right mesial temporal lobe epilepsy
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DOI：
10.1212/wnl.60.3.426
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发表时间：
2003-02-11
期刊：
影响因子：
9.9
通讯作者：
Tassinari, CA
中科院分区：
文献类型：
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作者：
Meletti, S;Benuzzi, F;Tassinari, CA
背景：前内侧颞叶区域，特别是杏仁核，参与面部表情的情绪识别。作者研究了症状性癫痫受试者的面部情绪识别（ER）能力，评估内侧颞叶损伤是否与特定情绪识别障碍有关，以及在生命的关键时期癫痫发作是否可以阻止ER的发展。研究方法：各组包括MRI显示内侧颞叶硬化（MTS）的颞叶癫痫（TLE）患者（n = 33）; MRI显示除MTS外颞叶病变的TLE患者（n = 30）;以及颞外癫痫患者（n = 33）。健康志愿者（n = 50）作为对照。ER通过将面部表情与以下基本情绪之一的名称进行匹配来进行测试：快乐，悲伤，恐惧，厌恶和愤怒。面孔匹配任务被用来控制视觉感知能力与面部刺激。结果：没有被试在面孔匹配任务中表现出缺陷。ER在右侧MTS患者中受损，特别是对于恐惧的面孔。出现左侧MTS、右侧或左侧颞叶病变（MTS除外）或颞外癫痫灶的患者的ER表现与对照组相似。在所有右侧TLE患者中，情绪识别障碍的程度与首次癫痫发作（发热或无发热）的年龄和癫痫发作的年龄有关。结论：早发性右侧内侧颞叶癫痫是确定面部表情识别严重缺陷的关键基质，特别是恐惧。
Background: Anteromedial temporal lobe regions, particularly the amygdala, participate in the recognition of emotions from facial expressions. The authors studied the ability of facial emotion recognition (ER) in subjects with symptomatic epilepsy, evaluating whether mesial temporal lobe damage is related to an impairment in the recognition of specific emotions and whether the onset of seizures in a critical period of life could prevent the development of ER. Methods: Groups included patients with temporal lobe epilepsy (TLE) with MRI evidence of mesial temporal sclerosis (MTS) (n = 33); patients with TLE with MRI evidence of temporal lobe lesions other than MTS (n = 30); and patients with extratemporal epilepsy (n = 33). Healthy volunteers (n = 50) served as controls. ER was tested by matching a facial expression with the name of one of the following basic emotions: happiness, sadness, fear, disgust, and anger. A face-matching task was used to control visuoperceptual abilities with face stimuli. Results: No subject showed deficits in the face-matching task. ER was impaired in patients with right MTS, especially for fearful faces. Patients presenting left MTS, right or left temporal lobe lesions other than MTS, or extratemporal seizure foci showed ER performances similar to controls. In all subjects with right TLE, the degree of emotion recognition impairment was related to age at first seizure (febrile or afebrile) and age at epilepsy onset. Conclusions: Early-onset right-sided mesial temporal lobe epilepsy is the key substrate determining a severe deficit in recognizing emotional facial expressions, especially fear.