Information theory applied to chromatographic fingerprint of herbal medicine for quality control
Information theory applied to chromatographic fingerprint of herbal medicine for quality control
复制标题
DOI：
10.1016/s0021-9673(03)00648-4
复制
发表时间：
2003-06-20
影响因子：
4.1
通讯作者：
Chau, FT
中科院分区：
文献类型：
--
作者：
Gong, F;Liang, YZ;Chau, FT
目前。指纹图谱的构建对复杂中药的质量控制具有重要作用。本文应用信息论方法获得了性能良好的色谱指纹图谱。并根据指纹图谱的特点，对信息量的计算方法进行了改进。通过对多个色谱指纹图谱信息量的比较，确定了分离度高、化学成分浓度分布均匀、可靠的色谱指纹图谱。将改进的信息论方法应用于不同产地的真实的中药川芎、银杏等的模拟指纹图谱，结果表明该方法合理可靠，操作简便。分离度高、化学成分浓度分布均匀的色谱指纹图谱也可作为中药的特征成分，用于质量控制。(C)出版社：Elsevier Science B.V.
At present. the construction of chromatographic fingerprints plays an important role in the quality control of complex herbal medicines. In this work, information theory was applied to obtain chromatographic fingerprints with good performance. Moreover, according to the characteristics of the chromatographic fingerprints obtained, some modifications of the calculation of the information content were conducted. In comparison with the information content from several chromatographic fingerprints obtained, reliable chromatographic fingerprints with a high separation degree and uniform concentration distribution of chemical components could be determined. The successful application of information theory with modification to simulated chromatographic fingerprints together with real herbal medicines such as Rhizoma chuanxiong and Ginkgo biloba from different sources demonstrated clearly that the proposed method to determine chromatographic fingerprints was reasonable and reliable and it was user-friendly. Chromatographic fingerprints determined with high separation degrees and uniform concentration distribution of chemical ingredients might also chemically represent characteristic components of herbal medicines for quality control. (C) 2003 Published by Elsevier Science B.V.