Thermosensitive and Photocleavable Polyaspartamide Derivatives for Drug Delivery
Thermosensitive and Photocleavable Polyaspartamide Derivatives for Drug Delivery
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用于药物输送的热敏和光裂解聚天冬酰胺衍生物
DOI：
10.1002/pola.28171
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发表时间：
2016-09-15
影响因子：
--
通讯作者：
Jiang, Xulin
中科院分区：
文献类型：
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作者：
Du, Xiao;Jiang, Yibo;Jiang, Xulin
The development of novel thermo- and photo-dual-responsive biodegradable polymeric micelles based on amphiphilic polyaspartamide derivatives (NB-g-PHPA-g-mPEG) for anticancer drug delivery is reported. The obtained polymers containing hydrophobic photocleavable o-nitrobenzyl groups exhibit thermo-and photosensitivity. The micelles and paclitaxel-loaded micelles based on the thermo-and photo-dual-sensitive polymers were prepared by a quick heating method without using toxic organic solvent. The paclitaxel release from the drug-loaded micelles can be triggered under photoirradiation. Enhancement of the anticancer activity against HeLa cells was observed for paclitaxel-loaded NB-g-PHPA-g-mPEG micelles after light irradiation, while the empty NB-g-PHPA-g-mPEG micelles with or without irradiation did not show any toxicity. Therefore, the thermoand photo-dual-responsive NB-g-PHPA-g-mPEG micelles have a promising future applied as a light controlled drug delivery system for anticancer drugs. (C) 2016 Wiley Periodicals, Inc.
