MicroRNA Regulation of Epithelial to Mesenchymal Transition.
MicroRNA Regulation of Epithelial to Mesenchymal Transition.
复制标题
DOI：
10.3390/jcm5010008
复制
发表时间：
2016-01-14
影响因子：
3.9
通讯作者：
Allgayer H
中科院分区：
文献类型：
--
作者：
Abba ML;Patil N;Leupold JH;Allgayer H
上皮到间质转化（EMT）是一个中央调控程序，在许多方面与胚胎形态发生的几个步骤相似。除了在组织修复和伤口愈合中发挥生理作用外，EMT 还有助于化疗耐药、转移扩散和纤维化等。传统上，从上皮表型到间充质表型的形态变化的特征是一组蛋白质的出现或丢失，这些蛋白质已被认为是 EMT 过程的标志物。与所有蛋白质一样，这些分子在转录和翻译水平上分别由转录因子和 microRNA 控制。一组发育转录因子构成了 EMT 级联的支柱，大量证据表明 microRNA 在很大程度上参与了间充质转化的成功协调，反之亦然，要么通过抑制不同组转录因子的表达，要么在协调 EMT 中充当其功能介质。本文剖析了 microRNA 对 EMT 的贡献，并分析了它们在此细胞过程中作用的分子基础。在这里，我们强调它们与核心转录因子的相互作用，例如锌指增强子 (E)-盒结合同源盒 (ZEB)、Snail 和 Twist 家族以及一些多能性转录因子。
Epithelial to mesenchymal transition (EMT) is a central regulatory program that is similar in many aspects to several steps of embryonic morphogenesis. In addition to its physiological role in tissue repair and wound healing, EMT contributes to chemo resistance, metastatic dissemination and fibrosis, amongst others. Classically, the morphological change from epithelial to mesenchymal phenotype is characterized by the appearance or loss of a group of proteins which have come to be recognized as markers of the EMT process. As with all proteins, these molecules are controlled at the transcriptional and translational level by transcription factors and microRNAs, respectively. A group of developmental transcription factors form the backbone of the EMT cascade and a large body of evidence shows that microRNAs are heavily involved in the successful coordination of mesenchymal transformation and vice versa, either by suppressing the expression of different groups of transcription factors, or otherwise acting as their functional mediators in orchestrating EMT. This article dissects the contribution of microRNAs to EMT and analyzes the molecular basis for their roles in this cellular process. Here, we emphasize their interaction with core transcription factors like the zinc finger enhancer (E)-box binding homeobox (ZEB), Snail and Twist families as well as some pluripotency transcription factors.