IKK inhibition prevents PM2.5-exacerbated cardiac injury in mice with type 2 diabetes.
IKK inhibition prevents PM2.5-exacerbated cardiac injury in mice with type 2 diabetes.
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DOI：
10.1016/j.jes.2014.10.018
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发表时间：
2015-05
影响因子：
6.9
通讯作者：
Jinzhuo Zhao;Cuiqing Liu;Yuntao Bai;Tse-Yao Wang;H. Kan;Qinghua Sun
中科院分区：
文献类型：
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作者：
Jinzhuo Zhao;Cuiqing Liu;Yuntao Bai;Tse-Yao Wang;H. Kan;Qinghua Sun
Epidemiological studies have found that individuals with diabetes mellitus (DM) display an increased susceptibility for adverse cardiovascular outcomes when exposed to air pollution. This study was conducted to explore the potential mechanism linking ambient fine particles (PM2.5) and heart injury in a Type 2 DM (T2DM) animal model. The KKay mouse, an animal model of T2DM, was exposed to concentrated ambient PM2.5or filtered air for 8 weeksviaa versatile aerosol exposure and concentrator system. Simultaneously, an inhibitor of IκB kinase-2 (IKK-â) (IMD-0354), which is a blocker of nuclear factor κB (NF-κB) nuclear translocation, was administrated by intracerebroventricular injection (ICV) to regulate the NF-êB pathway. The results showed that ambient PM2.5induced the increase of, NF-êB, cyclooxygenase-2 (COX-2) and mitogen activated protein kinase (MAPK) expression in cardiac tissue, and that IMD-0354 could alleviate the inflammatory injury. The results suggested that the NF-êB pathway plays an important role in mediating the PM2.5-induced cardiovascular injury in the T2DM model. Inhibiting NFκB may be a therapeutic option in air-pollution-exacerbated cardiovascular injury in diabetes mellitus.
