Regeneration of the intestinal epithelia: regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells.
Regeneration of the intestinal epithelia: regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells.
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DOI：
10.1111/j.1749-0774.2006.00010.x
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发表时间：
2006-05-01
期刊：
影响因子：
4.3
通讯作者：
Watanabe, Mamoru
中科院分区：
文献类型：
--
作者：
Okamoto, Ryuichi;Matsumoto, Tomoko;Watanabe, Mamoru
肠上皮细胞由四种分化细胞谱系组成，所有这些细胞都来自于肠隐窝中的干细胞。为了从上皮损伤中适当再生，认为需要上皮细胞数量的扩增和从剩余干细胞的谱系分化的适当调节。在一系列的研究中，我们发现骨髓来源的细胞可以促进人肠道受损上皮细胞的再生。移植物抗宿主病后骨髓移植受者胃肠道上皮细胞再生过程中，供体来源的上皮细胞大量再生。此外，上皮细胞谱系的精确分析显示，在上皮再生过程中，来源于骨髓的分泌谱系上皮细胞的数量显著增加。这些发现可能会导致一种新的治疗方法，以修复受损的肠上皮细胞使用骨髓细胞，并提供一种替代治疗难治性炎症性肠病。
The intestinal epithelia consists of four lineages of differentiated cells, all of which arise from stem cells residing in the intestinal crypt. For proper regeneration from epithelial damage, both expansion of the epithelial cell number and appropriate regulation of lineage differentiation from the remaining stem cells are thought to be required. In a series of studies, we have shown that bone-marrow derived cells could promote the regeneration of damaged epithelia in the human intestinal tract. Donor-derived epithelial cells substantially repopulated the gastrointestinal tract of bone-marrow transplant recipients during epithelial regeneration after graft-versus-host disease. Furthermore, precise analysis of epithelial cell lineages revealed that during epithelial regeneration, secretory lineage epithelial cells that originated from bone-marrow significantly increased in number. These findings may lead to a novel therapy to repair damaged intestinal epithelia using bone marrow cells, and provide an alternative therapy for refractory inflammatory bowel diseases.