INTERICTAL SPIKE-WAVE COMPLEXES IN THE HUMAN MEDIAL TEMPORAL-LOBE - TYPICAL TOPOGRAPHY AND COMPARISONS WITH COGNITIVE POTENTIALS
INTERICTAL SPIKE-WAVE COMPLEXES IN THE HUMAN MEDIAL TEMPORAL-LOBE - TYPICAL TOPOGRAPHY AND COMPARISONS WITH COGNITIVE POTENTIALS
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DOI：
10.1016/0013-4694(86)90138-0
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发表时间：
1986-06-01
期刊：
影响因子：
--
通讯作者：
CRANDALL, PH
中科院分区：
文献类型：
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作者：
ALTAFULLAH, I;HALGREN, E;CRANDALL, PH
16例复杂部分性癫痫中，10例表现为发作间期棘慢波序列，形态和深度电压地形图具有特征性。“典型的慢波”(TSW)持续300-600毫秒，通常是最大的，在前海马区为负，在杏仁核为阳性。同侧扣带回、辅助运动、眶前叶和后来的颞叶皮质以及对侧内侧颞叶(MTL)的同步记录显示，只有很小的、明显的容量传导的波形。在TSW期间，同时记录到的局灶性MTL内的多单位活动被深刻地抑制。TSW传播到头皮，产生大量广泛的阳性反应。在一个简单的辨别任务中，从MTL到不频繁音记录了一个与头皮-P3类似的潜伏期和任务相关的大的内源性电位。这种“深度-P3”在MTL位置上具有非常相似的极性和相对幅度，就像在相同电极接触下观察到的TSW一样。然而，在较浅的颅内部位，TSW相对小于P3。类似地，从MTL到表面，P3的减量大约是TSW减量的一半。这一证据表明，表面P3是由MTL产生的，但只是部分地。
Ten of 16 patients with complex partial epilepsy displayed an interictal spike-slow wave sequence with characteristic morphology and depth voltage topography. The ''typical slow wave'' (TSW) lasted 300-600 msec, was usually largest and negative in the anterior hippocampus, and positive in the amygdala. Simultaneous recordings from ipsilateral cingulate, supplementary motor, orbitofrontal, and later temporal cortices, as well as from the contralateral medial temporal lobe (MTL), revealed only small, apparently volume-conducted, wave forms. Simultaneously recorded multiunit activity within the focal MTL was profoundly inhibited during the TSW. The TSW propagated to the scalp, producing a large widespread positivity. A large endogenous potential with similar latency range and task correlates as the scalp-P3 was recorded from the MTL to infrequent tones in a simple discrimination task. This ''depth-P3'' had very similar polarity and relative amplitude across MTL sites, as was observed for the TSW at the same electrode contacts. However, at more superficial intracranial sites, the TSW was relatively smaller than the P3. Similarly, from MTL to surface, the P3 was found to decrement about half as much as the TSW decrements. This evidence suggests that the surface P3 is generated, but in part only, by the MTL.