Zeb1 promotes androgen independence of prostate cancer via induction of stem cell-like properties
Zeb1 promotes androgen independence of prostate cancer via induction of stem cell-like properties
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DOI：
10.1177/1535370214538727
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发表时间：
2014-07-01
影响因子：
3.2
通讯作者：
Gao, Wei-Qiang
中科院分区：
文献类型：
--
作者：
Li, Ping;Wang, Jia;Gao, Wei-Qiang
Current androgen deprivation therapy often leads to androgen independence. However, mechanism of the therapeutic failure is still not well understood. Here, we demonstrate elevated expression of Zeb1 in androgen-independent prostate cancer cells and prostate tumors of castrated PTEN conditional knockout mice. While Zeb1 shRNA resulted in a sensitization of androgen-independent prostate cancer cells, forced Zeb1 expression caused androgen-dependent prostate cancer cells to be more resistant to androgen deprivation. Moreover, such effects appeared to be mediated by induction of pluripotent genes or stem cell-like properties. Collectively, these findings suggest that inhibition of Zeb1 might be a potential therapeutic strategy for treatment of androgen-independent prostate cancer.
