STRAIN OF PLASMODIUM-VIVAX CHARACTERIZED BY PROLONGED INCUBATION - EFFECT OF NUMBERS OF SPOROZOITES ON LENGTH OF PRE-PATENT PERIOD
STRAIN OF PLASMODIUM-VIVAX CHARACTERIZED BY PROLONGED INCUBATION - EFFECT OF NUMBERS OF SPOROZOITES ON LENGTH OF PRE-PATENT PERIOD
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DOI：
10.1016/0035-9203(76)90132-2
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发表时间：
1976-01-01
影响因子：
2.2
通讯作者：
GARNHAM, PCC
中科院分区：
文献类型：
--
作者：
SHUTE, PG;LUPASCU, G;GARNHAM, PCC
朝鲜株间日疟原虫的特点是在某些情况下潜伏期特别长。定量观察清楚地表明，这种现象可能是由接种少量子孢子引起的。皮内接种10或100个子孢子后，潜伏期延迟262至628天不等;接种1，000个子孢子后，除一个例外，出现相同的延迟;在十万个子孢子之后，潜伏期一直是正常的（13-16天）。在服用预防性药物的工人中发生的两例实验室获得性感染显示潜伏期为315天和329天，各种理论的现象延长的预开放期进行了检查，最令人满意的一个是基于假定存在两个群体的子孢子在P。间日疟原虫在温和型菌株中，需要长的开放前期（LPP）才能发育的子孢子大量存在，而以短的开放前期（SPP）为特征的子孢子的比例要小得多;因此，小剂量会引起这种现象，尽管超过1，000个子孢子的剂量会掩盖这种效应，因为少数SPP子孢子会产生具有正常（即短）开放前期的感染。在热带菌株中，相对比例是不同的，可能数量相等，即使在小剂量下也会出现一些SPP子孢子，无论剂量如何，正常的开放前期都应该随之而来。
The North Korean strain ofPlasmodium vivaxwas characterized by its extraordinarily prolonged incubation period in certain circumstances. It was clearly demonstrated by quantitative observations that the phenomenon may be elicited by the inoculation of small numbers of sporozoites. After the intradermal inoculation of 10 or 100 sporozoites, the incubation period was delayed for periods varying between 262 and 628 days; after 1,000 sporozoites, with one exception, the same delay occurred; after 100,000 sporozoites, the incubation period was always of normal duration (13–16 days).Two laboratory-acquired infections in workers who had taken a prophylactic drug showed incubation periods of 315 and 329 days, respectively.Various theories for the phenomenon of prolonged prepatent periods are examined, and the most satisfactory one is based on the presumed existence of two populations of sporozoites inP. vivax. In temperate strains, sporozoites requiring long prepatent periods (LPP) for development are present in great excess over a much smaller proportion of sporozoites characterized by short prepatent periods (SPP); thussmalldoses will elicit the phenomenon, though doses of over 1,000 sporozoites will mask the effect as the few SPP sporozoites will produce an infection with a normal (i.e. short) prepatent period. In tropical strains, the relative proportions are different, perhaps in equal numbers, and even in small doses some SPP sporozoites will be present and normal prepatent periods should ensue whatever the dosage.