DURATION OF INFECTION-DERIVED IMMUNITY TO CHOLERA
DURATION OF INFECTION-DERIVED IMMUNITY TO CHOLERA
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DOI：
10.1093/infdis/143.6.818
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发表时间：
1981-01-01
影响因子：
6.4
通讯作者：
YOUNG, CR
中科院分区：
文献类型：
--
作者：
LEVINE, MM;BLACK, RE;YOUNG, CR
4名志愿者用霍乱弧菌（106种经典Ogawa 395微生物）再激发33-36个月。4名退伍军人和5名对照志愿者中的4名在初次诱导霍乱感染后没有发生腹泻（P = 0.04）。所有对照组，但只有1名退伍军人，有积极的coprocultures。4名退伍军人中有3名在挑战前血清IgG抗毒素水平显著;没有可测量的肠道分泌型伊加抗毒素水平。血清杀弧菌和抗毒素抗体水平的显着上升发生在所有对照组和2名退伍军人，谁也表现出肠道分泌伊加抗毒素水平的上升。令人印象深刻的感染源性免疫力的持续时间表明，最有希望的霍乱疫苗的开发方法可能是模仿自然免疫与口服给药，减毒菌株的霍乱弧菌。
Four volunteers were rechallenged with Vibrio cholerae (106 classical Ogawa 395 organisms) 33-36 mo. after their initial induced cholera infection; none of the 4 veterans and 4 of 5 control volunteers developed diarrhea (P = 0.04). All control subjects, but only 1 veteran, had positive coprocultures. Three of the 4 veterans had significant levels of serum IgG antitoxin before challenge; none had measurable intestinal levels of secretory IgA antitoxin. Significant rises in levels of serum vibriocidal and antitoxic antibody occurred in all control subjects and in 2 veterans, who also manifested rises in levels of intestinal secretory IgA antitoxin. The impressive duration of infection-derived immunity suggests that the most promising approach to development of cholera vaccines may be to mimic natural immunity with orally administered, attenuated strains of V. cholerae.