Aerobic exercise and lipids and lipoproteins in patients with cardiovascular disease: a meta-analysis of randomized controlled trials.
Aerobic exercise and lipids and lipoproteins in patients with cardiovascular disease: a meta-analysis of randomized controlled trials.
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DOI：
10.1097/00008483-200605000-00002
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发表时间：
2006-05-01
期刊：
影响因子：
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通讯作者：
Franklin, Barry
中科院分区：
文献类型：
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作者：
Kelley, George A;Kelley, Kristi S;Franklin, Barry
目得：使用荟萃分析的方法来研究有氧运动对成人心血管疾病（CVD）的血脂和脂蛋白的影响。方法：通过电子数据库检索研究，从检索到的文章，包括评论和手工检索的参考文献列表的审查。入选标准为：（1）随机对照试验，（2）有氧运动≥ 4周作为干预，（3）1955年1月1日至2005年1月1日期间仅以英语发表的研究，（4）在期刊上或作为论文或硕士论文发表的研究，（5）≥ 18岁的人类受试者，（6）诊断为某种类型CVD的所有受试者，和（7）可获得的总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和/或甘油三酯（TG）的治疗前和治疗后数据。随机效应模型用于数据分析。结果：在3,000多篇研究综述中，共有10篇代表1,260名受试者（580名运动，680名对照）被纳入我们的分析。HDL-C在统计学上显著增加9%，（平均值+/- SEM，3.7 +/- 1.3 mg/dL; 95% CI，1.2 - 6.1 mg/dL），TG统计学显著降低11%（-19.3 +/- 5.4 mg/dL; 95% CI，-30.1至-8.5 mg/dL），但TC或LDL-C无统计学显著性降低（TC，-8.8 +/- 6.8 mg/dL; 95%CI，-22.3至4.7 mg/dL; LDL-C，-7.7 +/- 6.0 mg/dL; 95%CI，-19.5至4.2 mg/dL）。结论：本研究结果表明，慢性有氧运动可增加患有CVD的成人，尤其是男性的HDL-C并降低TG。
PURPOSE: Use the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults with cardiovascular disease (CVD).METHODS: Studies were retrieved via electronic databases, review of reference lists from retrieved articles, including reviews, and hand searching. Inclusion criteria were: (1) randomized controlled trials, (2) aerobic exercise >or=4 weeks as an intervention, (3) studies published in English language only between January 1, 1955 and January 1, 2005, (4) studies published in journals or as dissertations or master's theses, (5) human subjects >or=18 years, (6) all subjects diagnosed with some type of CVD, and (7) pre and post data available for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). Random-effects models were used for data analysis.RESULTS: Of the more than 3,000 studies reviewed, a total of 10 representing 1,260 subjects (580 exercise, 680 control) were included in our analysis. There was a statistically significant increase of 9% in HDL-C (mean +/- SEM, 3.7 +/- 1.3 mg/dL; 95% CI, 1.2 to 6.1 mg/dL) and a statistically significant decrease of 11% in TG (-19.3 +/- 5.4 mg/dL; 95% CI, -30.1 to -8.5 mg/dL), but no statistically significant decreases in TC or LDL-C (TC, -8.8 +/- 6.8 mg/dL; 95% CI, -22.3 to 4.7 mg/dL; LDL-C, -7.7 +/- 6.0 mg/dL; 95% CI, -19.5 to 4.2 mg/dL).CONCLUSIONS: The present findings suggest that chronic aerobic exercise increases HDL-C and decreases TG in adults, especially men, with CVD.