Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection
Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection
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介导小鼠移植排斥的细胞。
DOI：
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发表时间：
1981
影响因子：
15.3
通讯作者：
I. F. McKenzie
中科院分区：
文献类型：
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作者：
B E Loveland;P. M. Hogarth;R. Ceredig;I. F. McKenzie
在CBA小鼠中使用单克隆抗Lyt-1.1和Lyt-2.1抗体测定介导皮肤移植物排斥的细胞的Ly表型，所述CBA小鼠接受来自对C57 BL/6致敏的小鼠的CBA淋巴样细胞;即，由H-2和非H-2基因座引起的同种异体抗原差异。很明显，移植排斥完全是由于接种物中Lyt-1细胞的存在，而Lyt-123或Lyt-23细胞没有影响。此外，没有注意到Lyt-1和Lyt-2细胞之间的协同作用。在该模型中，细胞毒性T细胞和细胞毒性淋巴细胞前体均显示为Lyt-123，并且这些细胞可以从介导移植物排斥的致敏Lyt-1群体中耗尽。因此，细胞毒性T细胞不负责皮肤移植排斥，而是由Lyt-1细胞介导。这种T细胞是否不同于其他Lyt-1细胞（辅助性T细胞，介导迟发型超敏反应的T细胞）目前尚不清楚，但其他证据和传统概念将移植物排斥和迟发型超敏反应联系起来，认为它们是同一机制的不同表现。
The Ly phenotype of cells mediating skin graft rejection was determined using monoclonal anti-Lyt-1.1 and Lyt-2.1 antibodies in CBA mice that received CBA lymphoid cells from mice sensitized to C57BL/6; i.e., alloantigenic differences arising from the H-2 and non-H-2 loci. It was clear that graft rejection was due wholly to the presence of Lyt-1 cells in the inoculum and that Lyt-123 or Lyt-23 cells had no effect. Furthermore, no synergism was noted between Lyt-1 and Lyt-2 cells. In this model, both the cytotoxic T cell and cytotoxic lymphocyte precursors were shown to be Lyt-123 and these could be depleted from sensitized Lyt-1 populations that mediated graft rejection. Thus cytotoxic T cells are not responsible for skin graft rejection, but rather, this is mediated by an Lyt-1 cell. Whether this T cell is distinct from other Lyt-1 cells (T helper, T cells mediating delayed hypersensitivity) is not clear at present, but other evidence, and traditional concepts, link graft rejection and delayed type hypersensitivity as being different manifestations of the same mechanism.