A systematic review of definitions of extreme phenotypes of HIV control and progression.
A systematic review of definitions of extreme phenotypes of HIV control and progression.
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DOI：
10.1097/qad.0000000000000049
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发表时间：
2014-01-14
期刊：
影响因子：
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通讯作者：
Sandhu MS
中科院分区：
文献类型：
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作者：
Gurdasani D;Iles L;Dillon DG;Young EH;Olson AD;Naranbhai V;Fidler S;Gkrania-Klotsas E;Post FA;Kellam P;Porter K;Sandhu MS
对艾滋病毒临床谱两端的个体进行研究可以为艾滋病毒生物学提供宝贵的见解。用于定义这些个体的异源性标准可能会导致研究结果的不一致，并难以确定这些表型的生物学机制。在本系统评价中，我们正式量化了文献中极端表型术语定义的异质性，并确定了用于描述这些表型的常见定义和组成部分。我们评估了2000年1月1日至2012年3月15日期间发表的501项合格研究中的714种HIV极端表型定义，并确定了这些定义之间的实质性差异。这种定义的异质性可能代表了这些选择的个体的生物学内表型和临床进展特征的重要差异，表明需要统一定义。在这种情况下，我们能够确定现有定义中的共同组成部分，这些定义可以为HIV感染中这些表型的共识定义提供框架。
The study of individuals at opposite ends of the HIV clinical spectrum can provide invaluable insights into HIV biology. Heterogeneity in criteria used to define these individuals can introduce inconsistencies in results from research and make it difficult to identify biological mechanisms underlying these phenotypes. In this systematic review, we formally quantified the heterogeneity in definitions used for terms referring to extreme phenotypes in the literature, and identified common definitions and components used to describe these phenotypes. We assessed 714 definitions of HIV extreme phenotypes in 501 eligible studies published between 1 January 2000 and 15 March 2012, and identified substantial variation among these. This heterogeneity in definitions may represent important differences in biological endophenotypes and clinical progression profiles of individuals selected by these, suggesting the need for harmonized definitions. In this context, we were able to identify common components in existing definitions that may provide a framework for developing consensus definitions for these phenotypes in HIV infection.