Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge.
Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge.
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肺功能和肺部射线照相变化的后续研究在恢复严重的急性呼吸道综合征患者时。
DOI：
10.1378/chest.127.6.2119
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发表时间：
2005-06
期刊：
影响因子：
9.6
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Xie L;Liu Y;Xiao Y;Tian Q;Fan B;Zhao H;Chen W
随访北京小汤山医院SARS患者出院后肺功能及肺部影像学改变（定期检查），回顾性分析SARS患者的治疗策略。存活的SARS患者在出院后3个月内至少就诊两次，并在中国人民解放军总医院接受SARS相关冠状病毒（SARS-CoV）IgG抗体检测、肺功能检测、胸部X线摄影和/或高分辨率CT（HRCT）检查。回顾性分析在小汤山医院接受的治疗，并与后来的状况进行相关性分析。258例患者中有208例SARS-Co病毒IgG抗体阳性，其中21.3%（55/258）仍有肺弥散异常（Dlco < 80%的预测值）。通过对155例SARS-CoV IgG抗体阳性且Dlco ≥ 80%预测值的存活者与50例SARS-CoV IgG抗体阴性的存活者进行比较，发现53例SARS-CoV IgG抗体阳性且肺弥散异常的存活者的发热病程更长，糖皮质激素的剂量更大，吸氧和无创通气治疗的比例更高。对于这些患者，53例SARS-CoV IgG结果阳性和肺弥散异常的患者中有51例在大约1个月后接受了肺功能检查。80.4%的患者（51例患者中的41例）DLCO改善。在肺弥散异常的患者中，40/51例患者在肺影像学检查中显示肺纤维化改变，22例患者（55%）在1个月后显示肺纤维化改变改善。这些结果表明，SARS引起的肺纤维化改变主要发生在重症患者，并可能自我修复。在评价肺纤维化改变时，DLCO评分可能比HRCT更敏感。
To follow-up on the changes in lung function and lung radiographic pictures of severe acute respiratory syndrome (SARS) patients discharged from Xiaotangshan Hospital in Beijing (by regularly receiving examination), and to analyze retrospectively the treatment strategy in these patients. Surviving SARS patients were seen at least twice within 3 months after discharge and underwent SARS-associated coronavirus (SARS-CoV) IgG antibody testing, pulmonary function testing, and chest radiography and/or high-resolution CT (HRCT) examinations at Chinese PLA General Hospital. The treatments received at Xiaotangshan Hospital were analyzed retrospectively and were correlated to later status. Positive SARS-Co virus IgG antibody results were seen in 208 of 258 patients, with 21.3% (55 of 258 patients) still having a pulmonary diffusion abnormality (Dlco < 80% of predicted). By comparing the 155 survivors with positive SARS-CoV IgG antibody results and Dlco ≥ 80% predicted with the 50 patients with negative SARS-CoV IgG results, we found that 53 patients with positive SARS-CoV IgG results and a lung diffusion abnormality had endured a much longer course of fever and received larger doses of glucocorticoid, as well as higher ratios of oxygen inhalation and noninvasive ventilation treatment. For these patients, 51 of 53 patients with positive SARS-CoV IgG results and a lung diffusion abnormality underwent pulmonary function testing after approximately 1 month. Dlco improved in 80.4% of patients (41 of 51 patients). Of the patients with a lung diffusion abnormality, 40 of 51 patients showed lung fibrotic changes in the lung image examination and 22 patients (55%) showed improvement in lung fibrotic changes 1 month later. These findings suggest that lung fibrotic changes caused by SARS disease occurred mostly in severely sick patients and may be self-rehabilitated. Dlco scores might be more sensitive than HRCT when evaluating lung fibrotic changes.
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影响因子：
4
作者：
Cutroneo, KR
通讯作者：
Cutroneo, KR
影响因子：
19.7
作者：
Antonio, GE;Wong, KT;Ahuja, AT
通讯作者：
Ahuja, AT
DOI：
10.1016/s0140-6736(03)13412-5
发表时间：
2003-05-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Peiris JS;Chu CM;Cheng VC;Chan KS;Hung IF;Poon LL;Law KI;Tang BS;Hon TY;Chan CS;Chan KH;Ng JS;Zheng BJ;Ng WL;Lai RW;Guan Y;Yuen KY;HKU/UCH SARS Study Group
通讯作者：
HKU/UCH SARS Study Group
影响因子：
6.9
作者：
Chan, KS;Zheng, JP;Ip, MS
通讯作者：
Ip, MS
影响因子：
158.5
作者：
Lee, N;Hui, D;Sung, JJY
通讯作者：
Sung, JJY