Effect of feeding biotin on milk production and hoof health in lactating dairy cows: A quantitative assessment
Effect of feeding biotin on milk production and hoof health in lactating dairy cows: A quantitative assessment
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DOI：
10.3168/jds.2010-3682
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发表时间：
2011-03-01
影响因子：
3.5
通讯作者：
Rabiee, A. R.
中科院分区：
文献类型：
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作者：
Lean, I. J.;Rabiee, A. R.
本研究的目的是严格审查随机对照试验，评价补充生物素对泌乳奶牛产奶量和成分以及蹄健康的有效性，探索研究间异质性的来源，并评价发表偏倚。定量评估可以增加我们研究治疗（如生物素）对结果影响的统计功效。共有9篇论文（6篇生产研究和3篇蹄健康研究）符合荟萃分析的合格标准。八项研究评估了补充生物素的奶牛中不符合入选标准的各种蹄病变。对生物素处理的产奶反应进行了11次比较。提取的数据包括对照组和给药组中的奶牛数量、响应方差（标准误或标准差）和P值。获得的其他数据包括产犊前后的给药持续时间、胎次、奶牛品种、生物素类型和剂量、补充剂的给药方法和饲料类型。生物素使产奶量增加1.29 kg/头/天（95%置信区间= 0.35至2.18 kg），无异质性证据（I-2 = 0.0%）。处理不影响乳脂或蛋白质百分比，并且观察到增加脂肪和蛋白质产量的趋势。产奶量和成分结果不受产犊前治疗持续时间、产次或饮食类型的影响。生物素补充对蹄健康的评估表明，更多的研究改善了而不是负面或中性的结果。生物素处理对产奶量的影响相对较大，对脂肪和蛋白质产量的影响虽然不显著，但在方向和幅度上与牛奶反应一致。对生物素的蹄健康反应应鼓励进一步研究，以使用检查蹄状况和跛行的一致标准更有效地确定这些反应的性质。
Objectives of this study were to critically review randomized controlled trials, evaluate the effectiveness of supplementation with biotin on milk yield and composition and hoof health in lactating dairy cows, explore sources of heterogeneity among studies, and evaluate publication bias. Quantitative assessments can increase the statistical power with which we study the effect of treatments, such as biotin, on outcomes. A total of 9 papers, with 6 production and 3 hoof health studies, met the eligibility criteria for meta-analysis. Eight studies evaluated various hoof lesions in biotin-supplemented cows that did not meet the inclusion criteria. Eleven comparisons were made of milk production responses to biotin treatment. Data extracted included the number of cows in control and treatment groups, measures of variance of responses (standard error or standard deviation) and P-values. Other data obtained included the duration of treatment before and after calving, parity, breed of cow, type and dose of biotin, delivery method of supplementation, and types of diets. Biotin increased milk production by 1.29 kg per head per day (95% confidence interval = 0.35 to 2.18 kg) with no evidence of heterogeneity (I-2 = 0.0%). Treatment did not affect milk fat or protein percentages, and a trend to increase fat and protein yields was observed. Milk production and composition results were not influenced by duration of treatment before calving, parity, or diet type. Assessment of biotin supplementation on hoof health indicated that more studies had improved rather than negative or neutral outcomes. The effect of biotin treatment on milk production was relatively large and the effects on fat and protein yields, although not significant, were consistent in direction and magnitude with the milk response. The hoof health responses to biotin should encourage further studies to more effectively define the nature of these responses using consistent criteria for examination of hoof conditions and lameness.