Refractory dysmyelopoietic anemia and acute leukemia.
Refractory dysmyelopoietic anemia and acute leukemia.
复制标题
难治性骨髓生成障碍性贫血和急性白血病。
作者：
D. Rosenthal;W. Moloney
我们对117例难治性骨髓增生异常贫血（RDA）患者进行了为期6年的随访和研究。所有RDA患者至少有两种骨髓细胞系涉及异常增生，通常有三种。形态学上，该系列可分为55例以“红系”增生为主，62例以“髓系”增生为主。髓系组的急性白血病发生率为21/62(33.9%)，明显高于红系组的7/55（12.7%）。在117例病例中，64例在辐照大鼠宿主中使用植入扩散室（DC）进行骨髓培养研究。在RDA期，白血病的发生与DC的异常生长有高度的统计学意义。
One hundred and seventeen consecutive patients with refractory dysmyelopoietic anemia (RDA) were followed and studied over 6 yr. All RDA cases had at least two marrow cell lines involved with dysplasia and usually all three. Morphologically, the series could be divided into 55 cases that had primarily "erythroid" hyperplasia and 62 cases with primarily "myeloid" dysplasia. There was a significantly higher number of acute leukemias in the myeloid group, 21/62 (33.9%), than in the erythroid group, 7/55 (12.7%). Of the 117 cases, 64 had marrow culture studies performed using implanted diffusion chambers (DC) in an irradiated rat host. There was a highly statistically significant correlation between the development of leukemia and abnormal growth in DC during the RDA stage.