Phox2b, RTN/pFRG neurons and respiratory rhythmogenesis
Phox2b, RTN/pFRG neurons and respiratory rhythmogenesis
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DOI：
10.1016/j.resp.2009.03.007
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发表时间：
2009-08-31
影响因子：
2.3
通讯作者：
Kawakami, Kiyoshi
中科院分区：
文献类型：
--
作者：
Onimaru, Hiroshi;Ikeda, Keiko;Kawakami, Kiyoshi
在髓质腹侧的表面区表达phox2b的细胞被认为在中枢化疗接受和出生后生存中发挥作用。最近在成年大鼠和新生小鼠的研究发现，延髓吻侧腹外侧的phox2b免疫反应（ir）细胞群由谷氨酸能神经元组成，并表达神经动素I受体（NK1R），表明该细胞群可能与后锥状核相同。该区域至少部分与面旁呼吸组（pFRG）重叠，pFRG主要由参与呼吸节律产生的前吸气（Pre-I）神经元组成。最近，我们发现新生大鼠的面旁区Pre-I神经元（pFRG/Pre-I）确实表达Phox2b，并且对突触后CO2敏感。我们的研究结果表明，表达phox2b的pFRG/Pre-I神经元在呼吸节律产生和中枢化学接受中发挥作用，因此对产后生存至关重要。在这篇简短的综述中，我们重点介绍了这些最新发现，并讨论了pFRG/Pre-I神经元的功能作用。(C) 2009 Elsevier B.V.版权所有
Phox2b-expressing cells in the parafacial region of the ventral medulla are proposed to play a role in central chemoreception and postnatal survival. Recent findings in the adult rat and neonatal mouse suggest that the Phox2b-immunoreactive (ir) cell cluster in the rostral ventrolateral medulla is composed of glutamatergic neurons and expresses neurokinin I receptor (NK1R), indicating that the cluster may be identical to the retrotrapezoid nucleus. This region overlaps at least partly with the parafacial respiratory group (pFRG) composed predominantly of pre-inspiratory (Pre-I) neurons that are involved in respiratory rhythm generation. Recently, we showed that Pre-I neurons in the parafacial region (pFRG/Pre-I) in neonatal rats are indeed expressing Phox2b and are postsynaptically CO2 sensitive. Our findings suggest that Phox2b-expressing pFRG/Pre-I neurons play a role in respiratory rhythm generation as well as central chemoreception and thus are essential for postnatal survival. In this brief review, we focused on these recent findings and discuss the functional role of pFRG/Pre-I neurons. (C) 2009 Elsevier B.V. All rights reserved.