Development of a novel phantom using polyethylene glycol for the visualization of restricted diffusion in diffusion kurtosis imaging and apparent diffusion coefficient subtraction method
Development of a novel phantom using polyethylene glycol for the visualization of restricted diffusion in diffusion kurtosis imaging and apparent diffusion coefficient subtraction method
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DOI：
10.3892/br.2020.1359
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发表时间：
2020-12-01
影响因子：
2.3
通讯作者：
Asaumi, Junichi
中科院分区：
文献类型：
--
作者：
Khasawneh, Abdullah;Kuroda, Masahiro;Asaumi, Junichi
本研究旨在探讨聚乙二醇模是否有潜力作为磁共振成像(MRI)的标准模体，以便在扩散峰度成像(DKI)、ADC减影方法(ASM)和表观扩散系数(ADC)中显示受限扩散。采集0-120 mm的聚乙二醇模的扩散加权图像，进行后处理，生成ADC、DKI和ASM图像。ASM是最近发展起来的一种用于限制扩散成像的方法，该方法使用长可变回声序列的读出分割。随着聚乙二醇浓度的增加，ADC值减小。相反，DKI和ASM值的增加与聚乙二醇浓度的增加有关。建立了公式来表示聚乙二醇浓度与ADC值、DKI值和ASM值之间的关系。这些公式可用于确定模拟某些疾病(包括肿瘤和梗塞)的任意ADC、DKI和ASM值所需的聚乙二醇浓度。使用生物模体进行了验证实验，并澄清了PEG模体覆盖了先前临床研究中使用3T MRI报告的ADC和DKI值的范围。聚乙二醇酯模体可能对未来涉及限制扩散的磁共振研究有用。
The present study aimed to investigate whether polyethylene glycol (PEG) phantoms have the potential to be used as standard phantoms for magnetic resonance imaging (MRI) in order to visualize restricted diffusion in diffusion kurtosis imaging (DKI), the ADC subtraction method (ASM) and the apparent diffusion coefficient (ADC). Diffusion-weighted images of 0-120 mM PEG phantoms were captured to create ADC, DKI and ASM images with post-processing. ASM is a recently developed method for restricted diffusion imaging using the readout segmentation of long variable echo-train sequences. As the PEG concentration increases, the ADC value decreases. Conversely, an increase in DKI and ASM values is associated with increasing PEG concentration. Formulae were constructed to represent the association between PEG concentrations and ADC, DKI and ASM values. These formulae can be used to determine the required PEG concentrations to mimic arbitrary ADC, DKI and ASM values of certain diseases, including tumors and infarctions. Validation experiments were conducted using bio-phantoms and clarified that the PEG phantoms cover the range of ADC and DKI values reported in previous clinical research using 3T MRI. PEG phantoms may be useful for future MRI research involving restricted diffusion.