Seedless synthesis of gold nanorods using resveratrol as a reductant
Seedless synthesis of gold nanorods using resveratrol as a reductant
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白藜芦醇作为还原剂无核合成金纳米棒
DOI：
10.1088/0957-4484/27/16/165601
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发表时间：
2016-04-22
期刊：
影响因子：
3.5
通讯作者：
Yang, Bai
中科院分区：
文献类型：
--
作者：
Wang, Wenjing;Li, Jing;Yang, Bai
金纳米棒（GNRs）在当前的诊断和治疗应用中吸引了广泛的关注，这些应用要求GNRs的合成具有高产率、可调节的纵横比、尺寸单分散性和易于表面修饰。在以十六烷基三甲基溴化铵（CTAB）胶束为模板的种子介导法合成GNRs中，芳香族化合物的添加对提高GNRs的粒径单分散性具有重要作用，这对GNRs的合成方法的进一步优化具有重要意义。本论文以葡萄中具有抗氧化作用的天然多酚白藜芦醇为还原剂，采用无核合成法合成了粒径单分散性好、纵横比可调的GNRs。因此，纵向局域表面等离子体共振（LSPR）峰可在570至950 nm范围内调谐。我们的方法的成功归因于白藜芦醇的芳香结构和温和的还原性。将白藜芦醇嵌入CTAB胶束中，增强了CTAB的选择性吸附，从而促进了GNRs的各向异性生长。此外，白藜芦醇的温和还原能够通过避免二次成核来支持GNR生长，从而允许具有良好尺寸单分散性的GNR的无籽合成。作为一种化学预防剂，白藜芦醇在GNR合成中的结合将巩固GNR的治疗诊断应用。
Gold nanorods (GNRs) attract extensive attention in current diagnostic and therapeutic applications which require the synthesis of GNRs with high yields, adjustable aspect ratio, size monodispersity, and easy surface decoration. In the seed-mediated synthesis of GNRs using cetyl trimethyl ammonium bromide (CTAB) micelles as templates, the additives of aromatic compounds have been found to be important for improving the size monodispersity of the as-synthesized GNRs; this is hopeful in terms of the further optimization of the synthetic methodology of GNRs. In this work, resveratrol, a natural polyphenol in grapes with an anti-oxidization behavior, is employed as the reductant for the seedless synthesis of GNRs with a good size monodispersity and a tunable aspect ratio. Accordingly, the longitudinal localized surface plasmon resonance (LSPR) peak is tunable from 570 to 950 nm. The success of our approach is attributed to the aromatic structure and mild reducibility of resveratrol. The embedment of resveratrol into CTAB micelles strengthens the facet-selective adsorption of CTAB, and therewith facilitates the anisotropic growth of GNRs. In addition, the mild reducibility of resveratrol is capable of supporting GNR growth by avoiding secondary nucleation, thus allowing the seedless synthesis of GNRs with a good size monodispersity. As a chemopreventive agent, the combination of resveratrol in GNR synthesis will consolidate the theranostic applications of GNRs.