Caudate encodes multiple computations for perceptual decisions.
Caudate encodes multiple computations for perceptual decisions.
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DOI：
10.1523/jneurosci.2894-10.2010
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发表时间：
2010-11-24
期刊：
影响因子：
--
通讯作者：
Gold JI
中科院分区：
文献类型：
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作者：
Ding L;Gold JI
感知决策是一个复杂的过程，需要多次计算，包括感官证据的积累和对积累过程的持续评估，以用于预测和调整。实现这些计算可能涉及许多大脑区域之间的相互作用。对于与眼动行为相关的感知决策，感觉证据积累的神经相关性已经在几个皮层区域中被确定，包括额叶眼区和外侧顶内区，以及它们的直接皮层下目标之一，上级丘。这些结构也通过基底神经节间接连接。基底神经节通路被认为有助于知觉决策，但这种贡献的性质还有待直接研究。在这里，我们表明，在猴子进行反应时间视觉运动方向辨别任务，神经元的主要输入结构的基底神经节，尾状核，编码三个方面的决策：证据积累，评估和选择偏见。这些结果表明，基底神经节通路可以提供重要的信号，影响和评估知觉的决定，指导眼的行为。
Perceptual decision-making is a complex process that requires multiple computations, including the accumulation of sensory evidence and an ongoing evaluation of the accumulation process to use for prediction and adjustment. Implementing these computations likely involves interactions among many brain regions. For perceptual decisions linked to oculomotor actions, neural correlates of sensory evidence accumulation have been identified in several cortical areas including the frontal eye field and lateral intraparietal area, and one of their direct, subcortical targets, the superior colliculus. These structures are also connected indirectly, via the basal ganglia. The basal ganglia pathway has been theorized to contribute to perceptual decision-making, but the nature of this contribution has yet to be examined directly. Here we show that in monkeys performing a reaction-time visual motion direction-discrimination task, neurons in a primary input structure of the basal ganglia, the caudate nucleus, encode three aspects of decision-making: evidence accumulation, evaluation, and choice biases. These results indicate that the basal ganglia pathway can provide important signals to influence and assess perceptual decisions that guide oculomotor behavior.