Autoregulatory cerebral vasodilation occurs during orthostatic hypotension in patients with primary autonomic failure
Autoregulatory cerebral vasodilation occurs during orthostatic hypotension in patients with primary autonomic failure
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DOI：
10.1007/bf02292768
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发表时间：
2001-12-01
影响因子：
5.8
通讯作者：
Kaufmann, H
中科院分区：
文献类型：
--
作者：
Horowitz, DR;Kaufmann, H
目前尚不清楚自主神经衰竭患者在低血压时是否能自动调节脑血流量。本研究的目的是通过使用经颅多普勒超声研究倾斜性低血压前、中、后大脑中动脉血流速度的变化，来检测自主神经衰竭患者的大脑自身调节能力。对9例原发性自主神经衰竭患者进行了评估。同时记录患者仰卧位、平头倾斜60度及恢复水平位时的平均动脉压和大脑中动脉血流速度。结果如下：在倾斜性低血压期间，平均动脉压的下降幅度明显大于大脑中动脉平均血流速度的下降幅度(58%对36%，p
It is unclear whet-her patients with autonomic failure autoregulate cerebral blood flow during hypotension. The objective in this study was to examine cerebral autoregulatory capacity in patients with autonomic failure by studying changes in middle cerebral artery blood flow velocity using transcranial Doppler ultrasonography before, during, and after tilt-induced hypotension. Nine patients with primary autonomic failure were evaluated. Mean arterial pressure and middle cerebral artery blood flow velocity were simultaneously recorded while the patients were in the supine position, during 60 degrees head-up tilt, and after they were returned to the horizontal position. The results were as follows: during tilt-induced hypotension, mean arterial pressure decreased significantly more than middle cerebral artery mean blood flow velocity (58% versus 36%, p